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首页> 外文期刊>Journal of Tissue Engineering >Clinical and Experimental Advances in Regeneration of Spinal Cord Injury
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Clinical and Experimental Advances in Regeneration of Spinal Cord Injury

机译：脊髓损伤再生的临床和实验研究进展

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Spinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation settings and is multifactorial in that the patients suffer from motor and sensory impairments as well as many other complications throughout their lifetimes. Many clinical trials have been documented during the last two decades to restore damaged spinal cords. However, only a few pharmacological therapies used in clinical settings which still have only limited effects on the regeneration, recovery speed, or retraining of the spinal cord. In this paper, we will introduce recent clinical trials, which performed pharmacological treatments and cell transplantations for patients with SCI, and evaluate recent in vivo studies for the regeneration of injured spinal cord, including stem-cell transplantation, application of neurotrophic factors and suppressor of inhibiting factors, development of biomaterial scaffolds and delivery systems, rehabilitation, and the combinations of these therapies to evaluate what can be appropriately applied in the future to the patients with SCI.
机译：脊髓损伤（SCI）是临床康复中要处理的主要残疾之一，并且是多因素的，因为患者一生中都遭受运动和感觉障碍以及许多其他并发症。在过去的二十年中，已记录了许多临床试验来修复受损的脊髓。但是，仅在临床环境中使用的几种药理疗法对脊髓的再生，恢复速度或再训练仅具有有限的影响。在本文中，我们将介绍最近的临床试验，该试验对SCI患者进行了药理学治疗和细胞移植，并评估了最近的体内研究对受损脊髓的再生，包括干细胞移植，神经营养因子的应用和SCI抑制剂的应用。抑制因素，生物材料支架和输送系统的开发，康复以及这些疗法的组合，以评估将来可适当应用于SCI患者的方法。

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