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首页> 外文期刊>Journal of Toxicology and Environmental Health Sciences >Maternal and foetal toxicity induced by exposure to mixture of dimethoate and cypermethrin in albino rats
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Maternal and foetal toxicity induced by exposure to mixture of dimethoate and cypermethrin in albino rats

机译：接触乐果和氯氰菊酯的混合物对白化病大鼠的母婴毒性

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The use of pesticide mixture to combat increased resistance by pest, to single chemical insecticide has brought about an increase in the use of pesticide mixture from different class, with its attendant toxicity. The objective of this study was to evaluate the maternal and foetal toxicity associated with dimethoate and cypermethrin, the two insecticides that are normally mixed to reduce pest resistance. 100 confirmed-mated (gravid) females were assigned at random among the four groups (control – tap water only):?? group 1- very low dose-10 mg/kg/day of Cypermethrin (5.3% LD50) + 1.0 mg/kg/day Dimethoate (0.7% of LD50); group 2- intermediate dose- 19 mg/kg/day of Cypermethrin (10% LD50) + 1.4 mg/kg/day? Dimethoate (0.9% of LD50); and group 3- high dose-? 38 mg/kg/day of Cypermethrin (20% LD50) + 12.8 mg/kg/day? Dimethoate (8.5% of LD50). The regimens were administered orally at gestation days (GD) 6-20 to pregnant rats. The dams were examined for mortality, moribundity, pertinent behavioural changes and signs of overt toxicity. Animals were weighed on day 0, and once at every 3-day intervals during the dosing period and on GD 21. The pregnant rats were sacrificed by decapitation on GD 21, the uteri were removed and the fetuses examined for litter weight, size, resorption, sex ratio, absolute and relative organ weight. The results showed that combined pesticide exposure caused overt toxic signs in the dams. However, the maternal body weight and relative organ weight were not adversely affected except in the heart that showed significant alteration. Although, the litter weight was not adversely compromised, the result showed that the prenatal exposure to pesticide mixture caused increased foetal resorption, decreased the litter size and offsprings’ male/female ratio. The study concludes that prenatal co-exposure to cypermethrin and dimethoate has adverse consequences on some maternal and foetal parameters in albino rats.
机译：使用农药混合物来对抗害虫增加的对单一化学杀虫剂的抵抗力，导致使用不同类别农药混合物的增加，并伴随着毒性。这项研究的目的是评估与乐果和氯氰菊酯有关的母体和胎儿毒性，这两种杀虫剂通常混合使用以降低对害虫的抵抗力。在四组中随机分配了100名已确认交配（重度）的雌性（对照–仅自来水）：第1组-极低剂量的氯氰菊酯10 mg / kg /天（5.3％LD50）+ 1.0 mg / kg /天的乐果（0.7％LD50）;第2组-中间剂量-氯氰菊酯（10％LD50）+ 19 mg / kg /天？1.4 mg / kg /天？乐果（LD50的0.9％）;和第3组-高剂量？ 38毫克/公斤/天的氯氰菊酯（20％LD50）+ 12.8毫克/公斤/天？乐果（LD50的8.5％）。该方案在妊娠第6-20天经口服给予怀孕的大鼠。检查了大坝的死亡率，濒死度，相关行为变化和明显的毒性迹象。在第0天对动物称重，并且在给药期间和GD 21上每3天间隔称重一次。通过GD 21断头处死处死怀孕的大鼠，取出子宫并检查胎儿的胎仔重量，大小，吸收。 ，性别比，绝对和相对器官重量。结果表明，农药的联合暴露在大坝中引起明显的中毒迹象。然而，除了心脏有明显改变外，产妇体重和相对器官重量没有受到不利影响。尽管胎仔体重没有受到不利影响，但结果表明，产前暴露于农药混合物会导致胎儿吸收增加，胎仔数量减少以及后代的雌雄比例。该研究得出的结论是，产前共同暴露于氯氰菊酯和乐果对白化病大鼠的某些母体和胎儿参数有不利影响。

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