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首页> 外文期刊>Journal of Veterinary Internal Medicine >Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund‐Gr?sbeck syndrome) maintains normal clinical and cellular cobalamin status
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Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund‐Gr?sbeck syndrome) maintains normal clinical and cellular cobalamin status

机译：比格犬每日口服遗传氰钴胺素伴有遗传性钴胺素吸收不良（Imerslund-Gr？sbeck综合征），可维持正常的临床和细胞钴胺素状态

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Background Efficacy of PO cobalamin (Cbl) supplementation in dogs with hereditary Cbl malabsorption (Imerslund‐Gr?sbeck syndrome, IGS) is unknown. Objectives To evaluate PO Cbl supplementation in Beagles with IGS previously treated parenterally. We hypothesized that 1?mg cyano‐Cbl daily PO would maintain clinical and metabolic remission. Animals Three client‐owned Beagles with IGS and 48 healthy control dogs. Methods Prospective study. Daily PO cyanocobalamin (cyano‐Cbl; 1?mg) supplementation was monitored for 13 (2 dogs) and 8?months (1 dog). Health status was assessed by owner observations. Methylmalonic acid (MMA)‐to‐creatinine concentrations were measured using an ultra‐performance liquid chromatography‐tandem mass spectrometry (UPLC‐TMS) method on urine samples collected monthly. Concurrent measurements of serum MMA concentration (n?=?7; UPLC‐TMS) were available for 1 dog. Results All dogs remained in excellent health during PO supplementation. Urine MMA remained consistently low in 2 dogs (median, 2.5?mmol/mol creatinine; range, 1.2‐9; healthy dogs [n?=?30], median, 2.9?mmol/mol creatinine; range, 1.3‐76.5). Urine MMA ranged from 38.9‐84.9?mmol/mol creatinine during the first 6?months in 1 dog already known to excrete comparable amounts when supplemented parenterally. Brief antibiotic treatment for an unrelated condition after 6?months resulted in low urine MMA (median, 2.8?mmol/mol creatinine; range, 1.9‐4.8) for the next 7?months. All concurrent serum MMA concentrations (median, 651?nmol/L; range, 399‐919) before and after month 6 were within the established reference interval (393‐1476?nmol/L; n?=?48). Conclusions and Clinical Importance One milligram of cyano‐Cbl daily PO appears efficacious for maintaining normal clinical status and normal cellular markers of Cbl metabolism in Beagles with IGS.
机译：背景补充PO钴胺素（Cbl）对具有遗传性Cbl吸收不良（Imerslund-Gr？sbeck综合征，IGS）的犬的功效尚不清楚。目的评估先前经肠胃外治疗的IGS对小猎犬的PO Cbl补充作用。我们假设每日1 mg氰基Cbl可以维持临床和代谢缓解。动物三只拥有IGS的客户小猎犬和48只健康对照犬。方法进行前瞻性研究。监测每天补充PO cyanocobalamin（cyano-Cbl; 1？mg）13（2只狗）和8个月（1狗）。通过主人的观察评估健康状况。使用超高效液相色谱-串联质谱（UPLC-TMS）方法对每月收集的尿液样品测量甲基丙二酸（MMA）到肌酐的浓度。可以同时测量1只狗的血清MMA浓度（n？=？7; UPLC-TMS）。结果所有狗在补充PO期间均保持良好的健康状态。两只狗的尿液MMA始终保持较低水平（中位值为2.5？mmol / mol肌酐;范围为1.2-9;健康犬[n？=？30]，中位值为2.9？mmol / mol肌酐;范围为1.3-76.5）。已知一只狗的肠外补充尿液MMA在最初的6个月内为38.9-84.9？mmol / mol肌酐，已知的排泄量相当。在6个月后对无关疾病进行简短的抗生素治疗会导致接下来7个月的尿液MMA低（中位数为2.8？mmol / mol肌酐;范围为1.9-4.8）。在第6个月之前和之后，所有同时存在的血清MMA浓度（中位值651nmol / L;范围399-919）均在既定的参考区间内（393-1476nmol / L; n == 48）。结论和临床重要性每天服用1毫克氰基Cbl可以有效维持IGS小猎犬的正常临床状态和Cbl代谢的正常细胞标记。

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