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首页> 外文期刊>Journal of Xenobiotics >Toxicity effect of sub-chronic oral administration of class bitters? - a polyherbal formula on serum electrolytes and hematological indices in male Wistar albino rats
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Toxicity effect of sub-chronic oral administration of class bitters? - a polyherbal formula on serum electrolytes and hematological indices in male Wistar albino rats

机译：亚慢性口服类苦酒的毒性作用？ -雄性Wistar白化病大鼠血清电解质和血液学指标的多草药配方

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The indiscriminate administration of readyto- use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters? (CB) - a polyherbal formula prepared with Mondia whitei , Khaya senegalensis , Capparis erythrocarpus , Thoningia sanguinea and Xylopia aethiopica on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg –1 ) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg –1 body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia.
机译：由于存在潜在的健康风险，因此不加选择地使用即用型草药制剂已成为一个主要问题。该研究调查了苦味药的作用？ （CB）-用Mondia whitei，Keya senegalensis，Capparis erythrocarpus，Thoningia sanguinea和Xylopia aethiopica制备的多草药配方，对雄性Wistar白化病大鼠的血清电解质和血液学参数具有影响。对雄性Wistar白化病大鼠口服两次剂量（500和1000 mg kg-1）的多草药药物，为期9周。结果显示，与对照相比，施用500和1000 mg kg-1体重的CB记录到钠和氯的含量显着增加。但是，钾和碳酸氢盐的含量显着降低。研究结果还显示，雄性Wistar白化病大鼠的血液学参数，例如血红蛋白（Hb），堆积细胞体积（PCV），红细胞（RBC）和血小板水平显着降低（P≤0.05） ，与对照相比。在这项研究的实验大鼠中观察到的Hb，PCV，RBC和血小板浓度显着降低，表明CB可能对红细胞生成有不利影响。因此，这些观察结果表明，长期服用CB可能会导致肾脏疾病和贫血。

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