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首页> 外文期刊>Journal of Young Pharmacists >Effect of Fractions of Alcoholic Extract of Moringa oleifera Lam. Bark on Dexamethasone induced Insulin Resistance in Rats
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Effect of Fractions of Alcoholic Extract of Moringa oleifera Lam. Bark on Dexamethasone induced Insulin Resistance in Rats

机译：辣木酒精提取物馏分的影响。树皮对地塞米松诱导的大鼠胰岛素抵抗

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Objective: Alcoholic extract of the bark of Moringa oleifera Lam. (MO), (Moringaceae), has been experimentally evaluated previously for its insulin sensitizing potentials. In the quest to explore the possibility of the class of phytochemical(s) responsible for this experimental claim, the alcoholic extract was fractionated and evaluated for insulin sensitizing effect in rat model for insulin resistance. Methods: Alcoholic extract of MO was fractionated into, non-polar [petroleum ether (PEF)], moderately non-polar [ethyl acetate (EAF)] and polar [aqueous (AQF)] fractions. The fractions obtained were investigated for their insulin sensitizing properties in dexamethasone induced insulin resistance in rats. The bioactive fraction was analysed by spectroscopy for further characterization of phytochemical(s) present. Results: Acute treatment for 4 h with dexamethasone (1 mg/kg i.p.) in rats led to the development of impaired oral glucose tolerance. Treatment with pioglitazone and EAF abolished dexamethasone induced oral glucose intolerance (OGT). Dexamethasone (1 mg/kg s.c., once daily for 11 d) administration led to the development of insulin resistance, characterised by fasting hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired OGT and increased HOMA IR index. Treatments with EAF (140 mg/kg p.o.) and pioglitazone [PIO (10 mg/kg p.o.)] significantly prevented dexamethasone induced metabolic changes. Similarly, treatment with AQF (95 mg/kg p.o.) also significantly prevented metabolic changes due to dexamethasone except impaired OGT. In contrast PEF (15 mg/kg p.o.) failed to prevent these metabolic changes except hypertriglyceridemia. Conclusion: The present study reveals that triterpenoid and the polyphenols (procyanidin) class of phytochemicals detected in EAF of alcoholic extract of MO bark may be responsible for the prevention of dexamethasoneinduced insulin resistance in rats.
机译：目的：辣木树皮的酒精提取物。 （Moringaceae）（MO），先前已通过实验评估了其胰岛素致敏性。为了探索造成该实验要求的植物化学类别的可能性，对酒精提取物进行分级分离，并评估其在大鼠抗胰岛素模型中的胰岛素致敏作用。方法：将MO的酒精提取物分为非极性[石油醚（PEF）]，中等非极性[乙酸乙酯（EAF）]和极性[水性（AQF）]馏分。研究了所得级分在地塞米松诱导的大鼠胰岛素抵抗中的胰岛素敏感性。通过光谱分析生物活性级分以进一步表征存在的植物化学物质。结果：地塞米松（1 mg / kg i.p.）在大鼠中急性治疗4小时导致口服葡萄糖耐量降低。吡格列酮和EAF的治疗废除了地塞米松诱导的口服葡萄糖耐量（OGT）。地塞米松（1 mg / kg s.c.，每天一次，持续11天）导致胰岛素抵抗的发展，其特征是禁食高血糖，高胰岛素血症，高甘油三酸酯血症，OGT受损和HOMA IR指数升高。用EAF（140 mg / kg p.o.）和吡格列酮[PIO（10 mg / kg p.o.）]的治疗可显着预防地塞米松引起的代谢变化。同样，除OGT受损外，AQF（95 mg / kg p.o.）的治疗还显着预防了地塞米松引起的代谢变化。相反，PEF（15 mg / kg p.o.）除高甘油三酸酯血症外未能阻止这些代谢变化。结论：本研究揭示了在MO吠声醇提物的EAF中检测到的三萜类和多酚类（原花青素）类植物化学物质可能是预防地塞米松诱导的大鼠胰岛素抵抗的原因。

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