...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Young Pharmacists >Assessment of Therapeutic Outcome and Medication Adherence in Diabetics Consumed Insulin, Oral Hypoglycemics and Poly Herbal Drugs
【24h】

Assessment of Therapeutic Outcome and Medication Adherence in Diabetics Consumed Insulin, Oral Hypoglycemics and Poly Herbal Drugs

机译：糖尿病患者食用胰岛素，口服降糖药和多草药的治疗结果和药物依从性评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: The overwhelming of consumption of antidiabetes poly herbal products (PHP) would influence the outcomes of hyperglycemia management. The underlying reasons were yet to be reveled; thought to be the herb-drug interactions and delayed adherence towards the conventional anti-diabetes drugs. We hypothesized that consumption of poly herbal antidiabetes products would influence the therapeutic outcome while on treatment with Insulin, oral hypoglycemic (OHG) drugs and/or both. We also hypothesized that trends towards poly herbal antidiabetes products would change the adherence towards conventional drug treatments and life style modifications. Methods: A total of 1251 patients with both type 1 and 2 diabetes mellitus of age 20-60 year, their fasting blood sugar (FBS) >110 mg/dl and /or random blood sugar (RBS) >150 mg/dl and urine sugar level >50 mg/dl were enrolled. The patients used herbal products, steroids, pregnant and lactating women and diabetic micro vascular disorders were excluded. The physical and vital parameters, symptoms of hyper/hypoglycemia were monitored. Diabetes Self-Assessment Questionnaire 16 (DSMQ-16); the scale used to assess their glucose management, physical activity, dietary control and physician contact was administered to each patient as a measure of adherence to the treatment. Results: The adherence level towards Insulin was found to be decreased while oral hypoglycemic drugs showed well. The consumption of PHP was most prevalent as well as adherence level. The markers of hyperglycemia were found to be altered in patient consumed PHP along with OHG drugs ( p <0.05). The random blood sugar (RBS) levels were not found to be normalized ( p <0.05) while fasting blood sugar (FBS) were found to be responded ( p <0.05). Conclusion: The PHP had a significant influence on OGH drugs. Since the adherence towards Insulin was decreased and assumed OHG-herb interactions the hyperglycemia management was not carried out. We recommend noncompartment Pharmacokinetic as well as Pharmacodynamics studies along with therapeutic drug monitoring.
机译：简介：大量服用抗糖尿病多草药产品（PHP）将影响高血糖管理的结果。根本原因尚未揭晓;被认为是草药与药物之间的相互作用以及对常规抗糖尿病药物的延迟依从性。我们假设食用多草药抗糖尿病药会影响胰岛素，口服降糖（OHG）药物和/或两者的治疗效果。我们还假设，聚草药抗糖尿病产品的趋势将改变对常规药物治疗和生活方式改变的依从性。方法：总共1251例20-60岁的1型和2型糖尿病患者，其空腹血糖（FBS）> 110 mg / dl和/或随机血糖（RBS）> 150 mg / dl和尿糖水平> 50 mg / dl。患者使用草药产品，类固醇，孕妇和哺乳期妇女以及糖尿病性微血管疾病除外。监测身体和生命参数，高/低血糖症状。糖尿病自我评估问卷16（DSMQ-16）;将用于评估其葡萄糖管理，身体活动，饮食控制和医师接触的量表作为对治疗依从性的衡量标准。结果：发现对胰岛素的依从性降低，而口服降糖药表现良好。 PHP的使用以及遵守级别最为普遍。发现高血糖的标志物在患者食用的PHP和OHG药物中发生了改变（p <0.05）。未发现随机血糖（RBS）水平正常（p <0.05），而发现空腹血糖（FBS）有反应（p <0.05）。结论：PHP对OGH药物有重要影响。由于减少了对胰岛素的依从性并假定了OHG-药草相互作用，因此未进行高血糖管理。我们建议进行非房室药代动力学，药效学研究以及治疗药物监测。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号