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首页> 外文期刊>Journal of Young Pharmacists >Effectiveness of Sweet Orange Peel Extract (Citrus sinensis) on The Improvement of Liver Functions of Animal Trials Induced by Cigarette Smoke
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Effectiveness of Sweet Orange Peel Extract (Citrus sinensis) on The Improvement of Liver Functions of Animal Trials Induced by Cigarette Smoke

机译：甜橙皮提取物（Citrus sinensis）对改善香烟烟雾引起的动物试验肝功能的作用

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Objective: Cigarette smoke contains harmful substances such as molecular compounds, reactive oxygen and nicotine compounds that can increase levels of Serum Glutamate-Pyruvate Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT). Sweet orange peel extract is known to have good radical antioxidative potential and a hepatoprotective effect. This study purpose to know the effectiveness of sweet orange peel extract ( Citrus sinensis ) to improve the liver function of trials animal that induced by cigarette smoke. Methods: This research is experimental laboratory with pre-test and post-test with control group design. The research subjects were 25 white rats ( Rattus novergicus ) male Wistar strain that divided into 5 groups: P1 (negative control), P2 (positive control), P3 (sweet orange peel extract dose of 37,5 mg / kgBW), P4 (sweet orange peel extract dose of 75 mg / kgBW), P5 (sweet orange peel extract dose of 112,5 mg/kgBW). The differences in SGOT-SGPT levels of pre-test and posttest were conducted by Wilcoxon test. The inhibition of increased levels of SGOT-SGPT to determine the effectiveness of sweet orange extract to the improvement of liver function using Kruskal-Wallis test. Results: Significant differences and inhibition of increase of SGOT-SGPT level (p = 0,00). The most effective sweet orange peel extract inhibits elevated levels of SGOT-SGPT is group P5 (sweet orange peel extract dose of 112,5 mg / kgBW. Conclusion: The sweet orange peel extract ( Citrus sinensis ) can effectively improve the liver function of trials animal induced by cigarette smoke.
机译：目的：香烟烟雾中含有有害物质，例如分子化合物，活性氧和尼古丁化合物，它们会增加血清谷氨酸丙酮酸转氨酶（SGPT）和血清谷草酰乙酸转氨酶（SGOT）的水平。已知甜橙皮提取物具有良好的自由基抗氧化能力和保肝作用。本研究旨在了解甜橙皮提取物（柑桔提取物）改善香烟烟雾所致实验动物肝脏功能的有效性。方法：本研究是在实验实验室进行前测试和后测试的对照组设计。研究对象是25只白色大鼠（Rattus novergicus）雄性Wistar菌株，分为5组：P1（阴性对照），P2（阳性对照），P3（甜橙皮提取物剂量为37.5 mg / kgBW），P4（ P5（甜橙皮提取物剂量为1112.5 mg / kgBW），甜橙皮提取物剂量为75 mg / kgBW）。测试前和测试后SGOT-SGPT水平的差异通过Wilcoxon测试进行。使用Kruskal-Wallis检验抑制SGOT-SGPT水平升高，以确定甜橙提取物对改善肝功能的有效性。结果：SGOT-SGPT水平的显着差异和抑制作用（p = 0,00）。最有效的甜橙皮提取物抑制SGOT-SGPT升高水平是P5组（甜橙皮提取物剂量为112.5 mg / kgBW。结论）：甜橙皮提取物（Citrus sinensis）可以有效改善试验的肝功能香烟烟雾引起的动物。

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