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首页> 外文期刊>Journal of Young Pharmacists >Solubility and Dissolution Enhancement of Meropenem by Nano Suspension Approach
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Solubility and Dissolution Enhancement of Meropenem by Nano Suspension Approach

机译：纳米悬浮法增强美洛培南的溶解度和溶解度

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Objective: To prepare and evaluate the suitable nanosuspensions of Meropenem (BCS-IV drug) to increase its solubility and dissolution. Methodology: The meropenem nanosuspensions were prepared by emulsification solvent evaporation technique by applying ultrasonic energy through probe sonicator, where the organic phase of drug solution in methanol was emulsified in aqueous phase containing hydroxy propyl methyl cellulose as solubilizer and sodium lauryl sulphate as stabilizer. The prepared nanosuspensions were characterised for particle size, zeta potential, surface morphology by SEM, drug excipient compatibility by FTIR and DSC and conducted in-vitro drug release studies. Results: Results showed that the prepared nanosuspensions were having particle size range from 1 to 1000nm and the zeta potential from -10 to -20 mVs. Scanning electron microscopic pictures revealed that the obtained nanosuspension particles were spherical in shape with surface smoothness and in-vitro drug release studies notified that the prepared nanosuspensions showed increase in solubility and dissolution of meropenem when compared with the pure form. Conclusion: The nanosuspensions of meropenem could be successfully prepared and can be concluded that the nanosuspension formulation is a promising approach to increase the solubility and dissolution of BCS-IV drugs like meropenem.
机译：目的：制备和评估适宜的美洛培南（BCS-IV药物）纳米混悬剂，以增加其溶解度和溶解度。方法：采用乳化溶剂蒸发技术，通过探头超声仪施加超声能量制备美罗培南纳米混悬液，其中药物溶液的甲醇有机相在含有羟丙基甲基纤维素作为增溶剂和十二烷基硫酸钠作为稳定剂的水相中被乳化。制备的纳米混悬液的粒径，ζ电位，SEM形貌，FTIR和DSC对药物赋形剂的相容性进行了表征，并进行了体外药物释放研究。结果：结果表明，所制备的纳米悬浮液的粒径范围为1至1000nm，ζ电位为-10至-20 mVs。扫描电子显微镜照片显示，所获得的纳米悬浮颗粒为球形，具有表面光滑度，并且体外药物释放研究表明，与纯形式相比，所制备的纳米悬浮颗粒显示出美洛培南的溶解度和溶解度增加。结论：美洛培南的纳米混悬剂可以成功制备，并且可以得出结论，纳米混悬剂是增加美洛培南等BCS-IV药物溶解度和溶解度的有前途的方法。

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