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首页> 外文期刊>Journal of Young Pharmacists >Study on the Safety and Efficacy of Indonesian Combination Plant Extract in Cosmetics
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Study on the Safety and Efficacy of Indonesian Combination Plant Extract in Cosmetics

机译：印尼组合植物提取物在化妆品中的安全性和有效性研究

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Objective: To look for antioxidant, lightening and anti aging effects from combination of Indonesian plant consist of Centella asiatica, Camellia sinensis and Glycine max extract in propanediol (CCGE). Methodology: The study was carried out using DPPH scavenging activity for antioxidant effect and anti tyrosinase activity for lightening effect. The efficacy test on volunteers was performed using Mexameter MX 16 and Cutometer MPA 580 to measure skin melanin index, elasticity and firmness respectively. The dermatological safety test was conducted using Repeated Opened Patch Test (ROPT) and Single Closed Patch Test (SCPT), while HETCAM test was performed to evaluate irritation at ocular level. Result: At the concentration of 2%, CCGE has DPPH scavenging activity and anti tyrosinase activity of 70.56% and 52.76% respectively compared to ascorbic acid and kojic acid. The efficacy test showed that CCGE significantly increased skin elasticity and firmness after two and four weeks of application compared to base, but showed no significant effect on skin lightening. The dermatological safety test showed that CCGE did not cause any irritation or allergic skin reaction at the concentration of 5% for the ROPT and up to 3% for the SCPT. Meanwhile at the concentration of 5%, CCGE could cause allergic reaction in 4.0% of all subjects. The HETCAM test showed that CCGE is not irritant at the ocular level. Conclusion: These results concluded that CCGE is proven to be safe for human skin as well as at ocular level and could be used as cosmetic active ingredient for anti aging.
机译：目的：从印尼积雪草，山茶和甘草中的大豆最大提取物（CCGE）的组合中寻找抗氧化剂，美白和抗衰老的作用。方法：本研究是利用DPPH清除活性的抗氧化作用和抗酪氨酸酶活性的增亮作用进行的。使用Mexameter MX 16和Cutometer MPA 580对志愿者进行功效测试，分别测量皮肤黑色素指数，弹性和紧致度。使用重复开放性斑块试验（ROPT）和单次闭合性斑块试验（SCPT）进行皮肤病学安全性试验，同时进行HETCAM试验以评估对眼睛的刺激性。结果：在2％的浓度下，CCGE的DPPH清除活性和抗酪氨酸酶活性分别比抗坏血酸和曲酸高70.56％和52.76％。功效测试表明，与基础相比，CCGE在施用后两周和四周可以显着提高皮肤弹性和紧致度，但对增白皮肤没有显着影响。皮肤病学安全性测试表明，CCGE不会引起任何刺激或过敏性皮肤反应，ROPT浓度为5％，SCPT浓度高达3％。同时，在5％的浓度下，CCGE可能引起4.0％的所有受试者的过敏反应。 HETCAM测试表明CCGE在眼部没有刺激性。结论：这些结果表明，CCGE被证明对人体皮肤和眼睛都安全，可以用作抗衰老的化妆品活性成分。

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