• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Tuberculosis Research >Pre-Extensively Drug Resistant Tuberculosis (Pre-XDR-TB) among Pulmonary Multidrug Resistant Tuberculosis (MDR-TB) Patients in Bangladesh
【24h】

Pre-Extensively Drug Resistant Tuberculosis (Pre-XDR-TB) among Pulmonary Multidrug Resistant Tuberculosis (MDR-TB) Patients in Bangladesh

机译：孟加拉国肺部多药耐药结核病（MDR-TB）患者中的广泛耐药结核病（Pre-XDR-TB）

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background & Objectives: Emergence of drug resistant Tuberculosis (TB) is a major obstacle in the TB control programme of Bangladesh. This study was carried out to detect pre-extensively drug resistant TB (pre-XDR-TB) cases among the multidrug resistant TB (MDR-TB) patients in Bangladesh, as the early detection of pre-XDR-TB can guide clinicians in the appropriate modification of MDR-TB treatment regimen with effective drugs to prevent treatment failure. Methodology: A total of 68 MDR-TB cases were enrolled in this study. Multiplex Real-time PCR was done to detect pre-XDR-TB cases directly from sputum samples of MDR-TB patients. Results: Out of 68 MDR-TB cases 11 (16.18%) cases were detected as pre-XDR-TB. The resistant profile of the 11 pre-XDR-TB revealed 9 (81.82%) cases of fluoroquinolone (FLQ) resistant pre-XDR-TB and 2 (18.18%) cases of injectable second line (ISL) agent resistant pre-XDR-TB. Out of 11 pre-XDR-TB cases 7 (63.64%) cases had history of taking treatment for MDR-TB regularly, 1 (9.09%) case had history of taking treatment for MDR-TB irregularly and 3 (27.27%) cases had no history of taking treatment for MDR-TB. Conclusion: This study encountered a high rate of pre-XDR-TB cases along with a significant number of primarily resistant bacilli which is of concern in the management of MDR-TB. It is evident that Bangladesh is in urgent need to device strategies for rapid and early detection of pre-XDR-TB in order to prevent treatment failure of MDR-TB cases and also to halt the progression of MDR-TB cases to extensively drug resistant TB (XDR-TB), which is not only difficult but also very expensive to treat.
机译：背景与目的：耐药结核病（TB）的出现是孟加拉国结核病控制计划的主要障碍。这项研究旨在检测孟加拉国多药耐药结核病（MDR-TB）患者中广泛耐药的TB（pre-XDR-TB）病例，因为尽早发现XDRTB可以指导临床医生用有效药物适当改变耐多药结核病治疗方案，以防止治疗失败。方法：本研究共纳入68例耐多药结核病病例。进行了多重实时PCR，以直接从耐多药结核病患者的痰液样本中检测出XDR-TB前病例。结果：在68例耐多药结核病病例中，有11例（16.18％）被检测为XDR-TB前。 11例XDR-TB的耐药性显示9例（81.82％）氟喹诺酮（FLQ）耐药性XDR-TB和2例（18.18％）注射二线（ISL）剂耐药性XDR-TB 。在XDR-TB之前的11例病例中，有7例（63.64％）有定期接受耐多药结核病的治疗史，1例（9.09％）例有不定期接受MDR-TB治疗史，3例（27.27％）没有耐多药结核病的治疗史。结论：本研究遇到了高耐药结核病前病例以及大量耐药菌的治疗，这些耐药菌值得关注。显而易见的是，孟加拉国迫切需要采取措施，以快速，早期发现XDR-TB前的结核病，以防止耐多药结核病的治疗失败，并阻止耐多药结核病向广泛耐药结核病的进展。 （XDR-TB），不仅治疗困难，而且治疗费用也很高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号