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首页> 外文期刊>Journal of Young Pharmacists >Effects of Bungur Leaves (Lagerstroemia speciose (L.) Pres.) on Malondialdehyde and Blood Glucose Levels in Hyperglycemic Mice
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Effects of Bungur Leaves (Lagerstroemia speciose (L.) Pres.) on Malondialdehyde and Blood Glucose Levels in Hyperglycemic Mice

机译：Bungur叶（紫薇）对高血糖小鼠丙二醛和血糖水平的影响

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Background: Bungur leaves have saponins, tannins, ellagitannin and flavonoids that could function as antioxidant and antihyperglycemic. Bungur leaves also consumed in Indonesia people for their diabetes treatment for a long time. Objective: The aim of this research is to know bungur leaves as antioxidant and antihyperglycemic so that can be used in the alternative therapy of diabetes mellitus. Methods : Mice were made hyperglycemic using alloxan, except normal group. The study was carried out using 30 mice divided into 6 groups: normal group, negative group, positive group, and treated group with 3 dose variation from bungur leaves decoction and taken the data on day 0, 5, and 19. Results: The result in normal group, negative group (alloxan), positive group (glibenclamide), treatments group which given by doses 1.6 g/kgBW, 3.2 g/kgBW, 6.4 g/kgBW of MDA levels respectively 0.6993 nmol/mL; 4.1953 nmol/mL; 0.8462 nmol/mL; 4.2873 nmol/mL; 3.3700 nmol/mL; 2.0670 nmol/mL while blood glucose levels on 19th day respectively 107.6 mg/dL;149.2 mg/dL; 104 mg/dL; 93 mg/dL; 109.6 mg/dL; 104 mg/dL. MDA levels on 6.4 g/kgBW and the averages of MDA levels have different significantly with a positive group, while blood glucose levels showed all treatments groups doses has no different significantly with positive group analyzed statistically. Conclusion: Bungur leaves have an effect to decrease MDA levels but not as well as glibenclamide while they have an effect to decrease blood glucose as well as glibenclamide.
机译：背景：旺格树叶含有皂苷，单宁，鞣花单宁和类黄酮，它们可以用作抗氧化剂和降血糖药。印尼人长期食用糖尿病人的叶子后还食用了它们。目的：本研究的目的是了解枫树叶作为抗氧化剂和降血糖药，从而可用于糖尿病的替代疗法。方法：除正常组外，用四氧嘧啶使小鼠血糖升高。使用30只小鼠进行研究，该小鼠分为6组：正常组，阴性组，阳性组和治疗组，其从红叶汤中剂量变化3次，并在第0、5和19天获取数据。结果：结果正常组，阴性组（四氧嘧啶），阳性组（格列本脲），治疗组分别给予MDA水平1.6 g / kgBW，3.2 g / kgBW，6.4 g / kgBW 0.6993 nmol / mL。 4.1953 nmol / mL; 0.8462 nmol / mL; 4.2873 nmol / mL; 3.3700 nmol / mL;第19天的血糖水平分别为2.0670 nmol / mL和107.6 mg / dL; 149.2 mg / dL; 104毫克/分升; 93毫克/分升; 109.6毫克/分升; 104毫克/分升。 6.4 g / kgBW的MDA水平和MDA平均值与阳性组有显着差异，而血糖水平显示所有治疗组的剂量与阳性组无统计学差异。结论：牛肝叶具有降低MDA含量的作用，但不及格列本脲，但具有降低血糖和格列本脲的作用。

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