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首页> 外文期刊>Journal of Young Pharmacists >A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India
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A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India

机译：印度三级保健教学医院重症监护病房（ICU）每日定义剂量用药模式的研究

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Objective: The goal of study is to identify drug and antimicrobial utilization in ICUs by using daily defined dose. Material and Methods: Study was conducted at tertiary care teaching hospital. 100 patients in each medical, surgical and neurosurgical ICU were included. The data were recorded in preformed Case Record Form (CRF). Drugs were classified using the anatomical therapeutic chemical (ATC) classification system and drug utilization was measured as Daily Defined Dose (DDD)/100 bed days. Data were analyzed by Z and x2 test. Results: DDD/100 bed days of inotropes was 51.44 in medical ICU which was significantly (p<0.05) higher compared to surgical and neurosurgical ICU while DDD/100 bed days of gastrointestinal drugs was 44.52, 38.57 and analgesics was 34.5, 34.41 in surgical and neurosurgical ICU respectively which was significantly (p<0.05) higher as compared to medical ICU. More than two antimicrobials were prescribed in above 70% patients in all ICU. DDD/100 bed days of cephalosporin was 20.76 in medical ICU which was significantly(p<0.05) higher compared to surgical and neurosurgical ICU. DDD/100 bed days of aminoglycosides was 16.01, 17.65 and nitroimidazole was 10.3, 8.4 in surgical and neurosurgical ICU respectively which was significantly (p<0.05) higher compared to medical ICU. Among restricted antimicrobials according to antimicrobial policy of hospital. DDD/100 bed days of piperacillin+tazobactam and cefoperazone+sulbactam were significantly (p<0.05) higher in medical ICU. Levoflxoacin and vancomycin were highly sensitive antimicrobials followed by beta lactam antimicrobials with beta lactamase inhibitors in all ICUs. Conclusion: Polypharmacy was observed in ICU and antimicrobials widely prescribed in ICUs. Sensitivity of beta lactam along with beta lacatamase inhibitors was high.
机译：目的：该研究的目的是通过确定每日剂量确定ICU中的药物和抗菌药物利用情况。资料与方法：研究是在三级教学医院进行的。每个医疗，外科和神经外科ICU中包括100名患者。数据以预制的病例记录表（CRF）记录。使用解剖学治疗性化学（ATC）分类系统对药物进行分类，并以每日定义剂量（DDD）/ 100床日作为药物利用率。数据通过Z和x 2 检验进行分析。结果：药物ICU的正性肌力药的DDD / 100天数为51.44天，与外科和神经外科ICU相比，显着（p <0.05）高，而胃肠道药物的DDD / 100天数为44.52、38.57天，镇痛剂为34.5、34.41天与医疗ICU相比，分别显着（p <0.05）高。在所有ICU中，超过70％的患者处方了两种以上的抗菌药物。在医疗ICU中，头孢菌素的DDD / 100天病床天数为20.76，与外科和神经外科ICU相比，显着（p <0.05）高。在外科和神经外科ICU中，氨基糖苷类药物的DDD / 100张病床天数分别为16.01、17.65和硝基咪唑为10.3、8.4，与医学ICU相比显着更高（p <0.05）。根据医院的抗菌政策，在限制使用的抗菌药物中。在医疗ICU中，哌拉西林+他唑巴坦和头孢哌酮+舒巴坦的DDD / 100床日显着更高（p <0.05）。在所有ICU中，左氧氟沙星和万古霉素是高度敏感的抗菌药，其次是具有β-内酰胺酶抑制剂的β-内酰胺抗菌剂。结论：在ICU中观察到多药治疗，在ICU中广泛使用抗菌药物。 β-内酰胺与β-Lacatamase抑制剂的敏感性很高。

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