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首页> 外文期刊>Journal of Young Pharmacists >Preliminary Pharmacognostical and Phytochemical Screening of DiaKure–A Polyherbal Antidiabetic Formulation
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Preliminary Pharmacognostical and Phytochemical Screening of DiaKure–A Polyherbal Antidiabetic Formulation

机译：DiaKure – A多草药降糖药的初步药理和植物化学筛选

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Background: Diakure is an indigenously prepared hypoglycemic polyherbal formulation, containing mixture of Vetiveria zizanoides (root), Hemidesmus indicus (rhizome), Strychnos potatorum (seed), Salacia reticulata (bark), Holarhena antidysenterica (seed), Cassia auriculata (bark), Trigonella graecum (seed) and Acacia catechu (bark) and each individual herb has scientific background in treating diabetes. This study aimed to perform pharmacognostical evaluation, preliminary phytochemical evaluation, standardization, heavy metal analysis, pesticidal residual analysis and antimicrobial assay of DiaKure. Materials and Methods: 100 g of the powder mixture of all eight herbs mentioned above was boiled with 900 ml water for 30 min to produce the polyherbal mixture and this mixture was used for performing various tests. Results: Organoleptic characters and macroscopic characters such as colour, odour, taste, size and shape are evaluated under pharmacognostical evaluations and ash values, extractive values and loss on drying are considered under standardisation parameters and are reported. Phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, flavonoids, steroids, glycoside and sugars. The formulation has normal limits of heavy metal and pesticidal residue. Also, the aqueous mixture, during its antimicrobial assay, does not exhibit any antibacterial or anti-fungal activities. Conclusion: The result of this study validates the use of aqueous extract of DiaKure in ethnomedicine, favouring the isolation of antidiabetic agents from the extract of DiaKure. Since the study was conducted in a controlled and authenticated manner, all the evaluation measures used in the study can be used for the standardization of the above-said formulation.
机译：背景：Diakure是一种本地制备的降血糖多草药制剂，包含香根草（Ventiveria zizanoides）（根），Hemidesmus indicus（根茎），Strychnos potatorum（种子），Salacia reticulata（树皮），Holarhena antidysenterica（种子），Cassia auriculata（树皮），木瓜（种子）和金合欢（树皮）以及每种草药都具有治疗糖尿病的科学背景。这项研究旨在对DiaKure进行药理学评估，初步植物化学评估，标准化，重金属分析，农药残留分析和抗菌测定。材料和方法：将100克上述所有八种草药的粉末混合物与900毫升水煮沸30分钟，以制得多草药混合物，并将该混合物用于进行各种测试。结果：在药理学评价中评估了感官特性和宏观特性，例如颜色，气味，味道，大小和形状，在标准参数下考虑了灰分值，提取值和干燥失重，并进行了报告。提取物的植物化学筛选显示存在生物碱，单宁，皂角苷，类黄酮，类固醇，糖苷和糖。该制剂具有正常的重金属和农药残留限量。而且，水性混合物在其抗微生物测定期间不表现出任何抗菌或抗真菌活性。结论：这项研究的结果证实了DiaKure的水提物在民族药中的应用，有利于从DiaKure的提取物中分离抗糖尿病药。由于该研究是以受控和认证的方式进行的，因此该研究中使用的所有评估方法都可以用于上述制剂的标准化。

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