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首页> 外文期刊>Journal of Young Pharmacists >A Prospective Study to Evaluate Prescription Pattern of Second Line Antiretroviral Therapy Given to HIV Patients
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A Prospective Study to Evaluate Prescription Pattern of Second Line Antiretroviral Therapy Given to HIV Patients

机译：评价艾滋病毒患者二线抗逆转录病毒疗法处方模式的前瞻性研究

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Aims: To evaluate prescription pattern during second line Antiretroviral Therapy (ART) at tertiary care hospital. Despite a very large number of patient being covered under ART, there are limited data in Indian population regarding second line ART. Therefore, the present study was undertaken. Methods: After consultation with physician of ART plus centre, patient was interviewed and details of the patient’s case record was obtained. At each encounter on every 30th day patient’s investigations, opportunistic infections, adherence level, associated medical conditions, second line ART and other drug prescription was recorded in preformed case record form for the study. Results: Out of 70 patients, 16 patients [22.86%] had history of 2nd line ART from Private ART clinics and 54 patients [77.14%] were transferred from other government ART centers. Mean time to switching from first line to second line ART was 3.67±2.29 years in 63 patients. Most common ART regimen prescribed at the initiation of second line ART was tenofovir+ lamivudine+ atazanavir /ritonavir in 45 patients [64.29%] with 264 encounters. Most common opportunistic infection was ARI [recurrent respiratory infection] with 28.84% incidence. Conclusion: Irrational practice by private hospitals limits treatment options with increasing the chances of drug resistance. On the other hand NACO sponsored second line ART was given with a proper treatment protocol causes good compliance in patients.
机译：目的：评估三级医院二线抗逆转录病毒疗法（ART）期间的处方模式。尽管有大量患者接受抗逆转录病毒治疗，但印度人群中有关二线抗病毒治疗的数据有限。因此，进行了本研究。方法：在与ART plus中心的医生协商后，对患者进行了采访，并获得了患者病历的详细信息。在每隔30天的患者调查中的每次相遇中，均以预先建立的病例记录表形式记录患者的机会性感染，依从性水平，相关的医疗状况，二线抗逆转录病毒疗法和其他药物处方。结果：在70例患者中，有16例[22.86％]有来自私人ART诊所的2线抗病史，而54例[77.14％]是从其他政府ART中心转移的。 63例患者从一线抗病毒治疗切换到二线抗病毒治疗的平均时间为3.67±2.29年。二线抗病毒治疗开始时最常用的抗逆转录病毒疗法是替诺福韦+拉米夫定+阿扎那韦/利托那韦治疗45例患者[64.29％]，发生264次。最常见的机会性感染为ARI（反复呼吸道感染），发生率为28.84％。结论：私立医院的不合理做法限制了治疗选择，增加了耐药性的机会。另一方面，NACO赞助的二线抗逆转录病毒疗法给予了适当的治疗方案，可导致患者良好的依从性。

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