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Nanoparticles for the Treatment of Lung Cancers

机译：纳米粒子治疗肺癌

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On the row of various cancers in the world, the Lung cancer falls to number two in both female and male. Various surgical and non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, and radiotherapy are employed in the treatment of lung cancer. However, most of these techniques are costly, complex and lacks patient compliance. In case of chemotherapy, it is associated with lack of specific tumour targeting, with limited drug solubility leads insufficient amount of drug reaches to a tumor site. To overcome these demerits associated with chemotherapy, various types of nanoparticles (both organic and inorganic) are synthesized and studied in treating lung cancers. In this article, we have reviewed the various types of nanoparticles that have been used in treating lung cancers. This review was carried out by searches of relevant published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles. The following search terms were used: Lung cancer, Target delivery, animal models, Nanoformulation, Nanoparticles and Polymeric Nanoparticles.
机译：在世界上各种癌症中，肺癌在女性和男性中均排名第二。包括化学疗法，光动力疗法和放射疗法在内的各种外科和非外科疗法都用于治疗肺癌。然而，大多数这些技术昂贵，复杂并且缺乏患者依从性。在化学疗法的情况下，这与缺乏特异性的肿瘤靶向有关，药物溶解度有限导致不足量的药物到达肿瘤部位。为了克服与化学疗法有关的这些缺点，合成并研究了各种类型的纳米颗粒（有机和无机），用于治疗肺癌。在本文中，我们回顾了用于治疗肺癌的各种类型的纳米颗粒。通过对PubMed / Medline，Web of Science，clinicaltrials.gov，Cochrane系统评价数据库和Google Scholar中所有英语文章的相关发表的文章，评论和摘要进行搜索来进行此评价。使用以下搜索词：肺癌，靶标递送，动物模型，纳米制剂，纳米颗粒和聚合纳米颗粒。

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