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首页> 外文期刊>Journal of Young Pharmacists >Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid
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Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

机译：甲基丙烯酸合成阿替洛尔分子印迹固相萃取的本体和沉淀聚合方法比较

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Objective: Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample. Method: This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule. Result: The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol. Conclusion: Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample.
机译：目的：根据世界反兴奋剂机构（WADA）的规定，阿替洛尔是一种β受体阻滞剂，被禁止使用。这项研究的目的是合成用于从样品中提取阿替洛尔的分子印迹聚合物（MIP）。方法：本研究比较了本体聚合和沉淀聚合两种方法。 MIP是由甲基丙烯酸作为功能性单体，乙二醇二甲基丙烯酸丙二酯作为交联剂，过氧化苯甲酰作为引发剂，丁醇作为致孔溶剂，以替诺洛尔为模板分子而成功制备的。结果：结果表明，与沉淀聚合相比，本体聚合法生产的吸附剂具有良好的吸附能力和较小的颗粒。两种方法都对阿替洛尔具有选择性。结论：通常，MIP固相萃取是从样品中提取阿替洛尔的另一种方法。

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