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首页> 外文期刊>Journal of Young Pharmacists >Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics
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Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics

机译：罗莎木槿花黏液作为潜在的鼻黏膜黏附剂的实验及其某些抗焦虑药原位凝胶的表征

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Objective: The objective of the present study was to prepare mucoadhesive in situ nasal gels with mucilage isolated from hibiscus flower ( Hibiscus rosa sinesi s, family: malveceae) containing alprazolam. Methods-Nasal gels of alprazolam were prepared using three different concentration (0.5%, 1% and 1.5% w/v) of H Rosa mucilage (HRM) and synthetic polymers (Hydroxy propyl methyl cellulose and carbopol 934). In situ gels were prepared with mixture of pluronic F127 and mucoadhesive agent. Result: Evaluation of HRM showed that it was as safe as the synthetic polymer for nasal administration. Evaluation of the prepared gel was carried out, including determination of viscosity, texture profile analysis and mucoadhesive strength. In vitro drug permeation study was conducted with the gels prepared with and without permeation enhancer (0.5% w/v sodium taurocholate) using excised goat nasal mucosa. For the determination of any further histological changes, before and after in vitro permeation study of the gels, with and without the permeation enhancer was also conducted. In vivo experiment conducted in rabbits further confirms that in situ nasal gel prepared with HRM provided better bioavailability of alprazolam than the gels prepared from synthetic mucoadhesive polymer. Conclusion: It was observed that the nasal gel containing 0.5% HRM and 0.5% sodium taurocholate exhibited appropriate rheological, mechanical and mucoadhesive properties and showed better drug release profile. More over this formulation produced no damage to the nasal mucosa used for the permeation study, and absolute bioavailability was also higher compare to gels prepared from synthetic polymers.
机译：目的：本研究的目的是用含有阿普唑仑的芙蓉花（Hibiscus rosa sinesi s，family：malveceae）中分离的粘液制备粘膜粘附性鼻凝胶。方法：使用三种不同浓度（0.5％，1％和1.5％w / v）的H Rosa粘液（HRM）和合成聚合物（羟丙基甲基纤维素和carbopol 934）制备阿普唑仑的鼻用凝胶。用普朗尼克F127和粘膜粘附剂的混合物制备原位凝胶。结果：HRM的评估表明，它与鼻腔给药的合成聚合物一样安全。对制备的凝胶进行评估，包括确定粘度，质地分布分析和粘膜粘附强度。使用切除的山羊鼻粘膜，在有和没有渗透促进剂（0.5％w / v牛磺胆酸钠）制备的凝胶中进行体外药物渗透研究。为了确定任何进一步的组织学变化，还进行了在有和没有渗透促进剂的情况下对凝胶进行体外渗透研究的前后。在兔中进行的体内实验进一步证实，与由合成粘膜粘附性聚合物制备的凝胶相比，用HRM制备的原位鼻凝胶提供了更高的阿普唑仑生物利用度。结论：观察到含有0.5％HRM和0.5％牛磺胆酸钠的鼻凝胶具有适当的流变，机械和粘膜粘附特性​​，并具有更好的药物释放特性。此外，与由合成聚合物制得的凝胶相比，该制剂更不会对用于渗透研究的鼻粘膜产生损害，并且绝对生物利用度也更高。

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