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首页> 外文期刊>Journal of Young Pharmacists >A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics
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A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics

机译：Cuminosides Nanomedicine-的综述：癌症治疗的药理学方法

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As per various reasearch works, Cuminosides isolated from Rhizome of Syzigium cumini has a potential anticancer activity and extensive variety of Antibacterial, antifungal, antioxidative, anti inflamatory activities with absence of toxicity to normal cells of body. Objctives of this review article to clarify enhanced bioavailability and pharmacokinetic properties, acuumlating and absorbing power of this multitargeted drug Cuminosides in nanoformulation at tumor site. Literature survey of cuminoside nanoformulation. talks about its primary rule in viable disease treatment that it destroys particular malignant cells and minimizes there poisonous quality at tumor site. The hemolytic ratio of this formulation is 2.155% which is in the acceptable range for therapeutic applications. Cuminoside nanoformulation also promote uptake of cancer cells in passive targeting due to Enhanced Permeation and Retention” (EPR) effect. Nanocarriers of Cuminoside is made from ethyl cellulose and methylcellulose which readily release cuminoside into blood circulation by adhering to stomach mucousa. This property is responsible for its better anticancer property and it was initially detected using scanning electron microscopy analysis. Cuminoside nanoformulation also reduces effective dose of cisplatin and radiation to inhibit growth of cisplatin resistant ovarian cancer cells. Cuminoside nanoparticles also enhaces tumor reduction of tumor xenografts via dcreased expression of vascular Endothelial Growth Factor (VEGF) as well as COX2. By selectively choosing particle size, zeta potential, stability and targeting moiety, cuminosides nanoformulations can be targeted to specific cancer cells. Cuminosides in form of nanoformulations has numerous advantages including improved efficacy, tumor targeting, reduced systemic toxicity, compliance and convenience. Now a days cuminoside nanoformulation is considred as Abbreviated New Drug Application (ANDA) or New Drug Applications (NDAs).
机译：根据各种研究工作，从孜孜孜然的根茎中分离出的南瓜子苷具有潜在的抗癌活性，并且具有广泛的抗菌，抗真菌，抗氧化，抗炎活性，并且对人体正常细胞没有毒性。该综述文章的目的是阐明增强的生物利用度和药代动力学特性，在肿瘤部位纳米制剂中这种多靶点药物孜然糖苷的累积和吸收能力。孜然苷纳米制剂的文献调查。谈到其在可行的疾病治疗中的主要规则，即破坏特定的恶性细胞并使肿瘤部位的毒性最小化。该制剂的溶血率为2.155％，在治疗应用可接受的范围内。由于增强的“渗透和保留”（EPR）效应，Cuminoside纳米制剂还可以促进被动靶向中癌细胞的摄取。 Cuminoside的纳米载体是由乙基纤维素和甲基纤维素制成的，它们通过粘附在胃粘液上而易于将异丙基葡萄糖苷释放到血液循环中。该性质是其更好的抗癌性质的原因，最初是使用扫描电子显微镜分析法检测到的。黄瓜苷纳米制剂还降低了顺铂和放射线的有效剂量，以抑制顺铂耐药性卵巢癌细胞的生长。黄瓜苷纳米颗粒还通过降低血管内皮生长因子（VEGF）和COX2的表达来增强异种移植物的肿瘤形成。通过选择性地选择粒径，ζ电势，稳定性和靶向部分，可将孜然苷纳米制剂靶向特定的癌细胞。纳米制剂形式的Cuminosides具有许多优势，包括提高功效，靶向肿瘤，降低全身毒性，顺应性和便利性。如今，孜然苷纳米制剂被认为是新药申请（ANDA）或新药申请（NDA）的缩写。

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