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首页> 外文期刊>Journal of Young Pharmacists >Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients
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Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients

机译：二甲双胍和二甲双胍-磺脲类药物联合抗氧化作用在2型糖尿病患者中的比较

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Background: Even though oxidative stress is intensively studied for its role in diabetic nephropathy, the effectiveness of first-line medication on diabetes in preventing oxidative stress and diabetic nephropathy is still unknown. This study aimed to analyze 8-iso-Prostaglandin F2α, UACR, and their correlation on 114 type 2 diabetes mellitus patients who consumed metformin and the combination of metformin-sulfonylurea. Material and Method: Urinary 8-iso-Prostaglandin F2α was measured by ELISA and urinary albumin was measured by Bromocresol Green Albumin assay. Results: The results showed that HbA1c (p=0.038) and 8-iso-Prostaglandin F2α level higher in the combination group than in metformin group, but not for UACR (p=0.838). However, subgroup analysis on albuminuric patients (UACR>30 mg/g, n=55) showed no different in HbA1c and 8-iso- Prostaglandin F2α level between the medication groups. Linear regression analysis showed HbA1c (β=0.402, p=0.002) and the combination of metformin-sulfonylurea (β=0.364, p=0.004) were the most predictive factors for increased UACR after controlled by age, gender, IMT, systolic blood pressure, 8-iso-Prostaglandin F2α, smoking habit and exercise habit. Conclusion: In conclusion, metformin was more effective in decreasing 8-iso-Prostaglandin F2α level, an oxidative stress marker. The increase of HbA1c and the use of a combination of metformin-sulfonylurea contributed in increased UACR in this study.
机译：背景：尽管人们对氧化应激在糖尿病肾病中的作用进行了深入研究，但针对糖尿病的一线药物在预防氧化应激和糖尿病肾病中的有效性仍然未知。本研究旨在分析114例服用二甲双胍和二甲双胍-磺脲类药物联合使用的2型糖尿病患者的8-异前列腺素F2α，UACR及其相关性。材料与方法：采用ELISA法测定尿中的8-异前列腺素F2α，用溴甲酚绿白蛋白法测定尿中的白蛋白。结果：结果显示，联合治疗组的HbA1c（p = 0.038）和8-异前列腺素F2α水平高于二甲双胍组，但UACR则不高（p = 0.838）。然而，对蛋白尿患者的亚组分析（UACR> 30 mg / g，n = 55）显示，两组药物之间的HbA1c和8-异前列腺素F2α水平无差异。线性回归分析显示，HbA1c（β= 0.402，p = 0.002）和二甲双胍-磺脲类药物的组合（β= 0.364，p = 0.004）是受年龄，性别，IMT，收缩压控制后UACR增加的最预测因素，8-异前列腺素F2α，吸烟习惯和运动习惯。结论：总之，二甲双胍在降低氧化应激标记物8-异前列腺素F2α水平方面更有效。在这项研究中，HbA1c的增加和二甲双胍-磺脲类药物的联合使用导致UACR升高。

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