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首页> 外文期刊>Journal of Young Pharmacists >Evaluation of Adverse Drug Reactions in Tertiary Care Hospital of Kolkata, West Bengal, India
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Evaluation of Adverse Drug Reactions in Tertiary Care Hospital of Kolkata, West Bengal, India

机译：印度西孟加拉邦加尔各答三级护理医院的药物不良反应评估

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Objective: Drug is beneficial for the treatment, prevention or diagnosis of disease. However, adverse drug reactions (ADRs) associated with the use of drugs are also very common. Due to the lack of knowledge and awareness, many adverse incidents due to a drug remain unnoticed. Present study was conducted to evaluate the prevalence of adverse drug reactions in a tertiary care hospital in Kolkata, West Bengal, India. Method: Present study was an observational study based on the reports collected during July 2014 to June 2015 from different departments of a tertiary care hospital, with prior consent. The reports comprised of patients of age group ranging from 1 month to 85 years, of either sex. The causality assessment was done on the basis of “Naranjo’s Assessment Scale” and severity assessment was done in accordance with “Hartwig and Siegel scale”. Result: During the study period, among 529 prescriptions, adverse drug reactions was suspected in 287 patients. This comprised of 144 (50.17%) females and 143 (49.83%) males. According to Anatomical Therapeutic Chemical (ATC) Classification System, the drug mostly associated with adverse drug reactions was anti-infective agents (63.07%). The causality assessment according to Naranjo Scale showed 5% ADRs have definite, 40% probable and 55% possible correlation. Conclusion: In order to ensure a better treatment regimen and improve patients’ compliance, it is essential to reduce and prevent adverse drug reaction. Implementation of pharmacovigilance programs in the hospitals is thus essential to enhance the awareness regarding early detection, reporting, management and further prevention of Adverse Drug Reactions.
机译：目的：药物对疾病的治疗，预防或诊断是有益的。但是，与使用毒品有关的药物不良反应（ADR）也很常见。由于缺乏知识和认识，许多因药物引起的不良事件仍未引起注意。目前的研究是在印度西孟加拉邦加尔各答的一家三级医院评估药物不良反应的发生率。方法：本研究是一项观察性研究，其依据是2014年7月至2015年6月在事先获得同意的情况下从三级医院不同部门收集的报告。该报告包括年龄范围从1个月到85岁的男女患者。因果关系评估是根据“ Naranjo评估量表”进行的，严重性评估是根据“ Hartwig和Siegel量表”进行的。结果：在研究期间，在529份处方中，怀疑287例患者出现药物不良反应。其中包括144名（50.17％）女性和143名（49.83％）男性。根据解剖治疗化学（ATC）分类系统，与药物不良反应最相关的药物是抗感染药（63.07％）。根据Naranjo量表的因果关系评估显示，5％的ADR具有明确的关联，40％的概率和55％的可能关联。结论：为了确保更好的治疗方案并改善患者的依从性，减少和预防药物不良反应至关重要。因此，在医院中实施药物警戒计划对于提高人们对早期发现，报告，管理和进一步预防不良药物反应的认识至关重要。

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