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首页> 外文期刊>Journal of Young Pharmacists >Comparative Experimental Studies of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers against Two Different Models of Angiogenesis
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Comparative Experimental Studies of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers against Two Different Models of Angiogenesis

机译：血管紧张素转换酶抑制剂和血管紧张素II受体阻滞剂对两种不同血管生成模型的对比实验研究

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Objective: Angiogenesis, the formation of new capillary blood vessels. We have compared the effect of two Angiotensin-Converting Enzyme inhibitors (ACEIs) and two Angiotensin Receptor Blockers (ARBs) for its anti-angiogenic property to pinpoint their role in capillary growth. Methods: The anti-angiogenic activity of ACEIs (Lisinopril, Ramipril) and ARBs (Losartan, Valsartan) were evaluated by in-ovo using and in-vivo methods by using chick embryo Chorioallantoic membrane (CAM) assay and sponge implantation method respectively. All the test drugs were tested at three dose level and Suramin was considered as standard. Before coming to the final conclusion various parameters were studied like angiogenic score, the number of branching points and micro-vessels in CAM assay, whereas the determination of Hb content, wet weight of the implants and VEGF was carried out in sponge implantation model. Results: Among all the drugs Losartan, AT1R blocker has shown a promising anti-angiogenic effect against both the models. Valsartan has also shown modest anti-angiogenic activity but not as good as Losartan. Losartan has shown significant (p0.005) dose-dependent decrease in the number of blood vessels, new branching points, angiogenic score and the decrease in wet weight, Hb content and VEGF content in the implants compared to normal control group. There was no significant difference were observed in any of the parameters by ACEI. Conclusion: Losartan possesses a significant potential to inhibit angiogenesis and this property could be useful in controlling metastasis in malignant cancerous tumors.
机译：目的：血管生成，形成新的毛细血管。我们比较了两种血管紧张素转换酶抑制剂（ACEIs）和两种血管紧张素受体阻滞剂（ARBs）的抗血管生成特性，以查明它们在毛细血管生长中的作用。方法：分别采用卵内和体内方法，分别采用鸡胚绒毛尿囊膜（CAM）测定法和海绵植入法评价ACEIs（利西普利，雷米普利）和ARBs（Losartan，Valsartan）的抗血管生成活性。所有测试药物均以三个剂量水平进行了测试，并且将苏拉明视为标准剂量。在得出最终结论之前，研究了各种参数，如CAM法中的血管生成评分，分支点数和微血管，而在海绵植入模型中测定Hb含量，植入物的湿重和VEGF。结果：在所有的Losartan药物中，AT1R阻断剂对这两种模型均显示出有希望的抗血管生成作用。缬沙坦还显示出适度的抗血管生成活性，但不如氯沙坦。与正常对照组相比，氯沙坦在植入物中的血管数量，新的分支点，血管生成分数以及湿重，血红蛋白含量和血管内皮生长因子含量的降低显示出剂量依赖性的显着降低（p <0.005）。 ACEI的任何参数均未观察到显着差异。结论：氯沙坦具有抑制血管生成的巨大潜力，该特性可用于控制恶性癌肿瘤的转移。

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