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首页> 外文期刊>Journal of Young Pharmacists >Antipyretic, Anti-Inflammatory and Analgesic Effects of Leaf Extract of Drumstick Tree
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Antipyretic, Anti-Inflammatory and Analgesic Effects of Leaf Extract of Drumstick Tree

机译：鸡腿叶提取物的解热，消炎，镇痛作用

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Objectives: The aim was to investigate the antipyretic, anti-inflammatory and analgesic activity of ethanolic leaf extract of Moringa oleifera, commonly known as drumstick tree. Materials and Methods: The study is a randomized controlled experimental study. The experiments were carried out dividing the animals in six groups, each containing six animals. Ethanolic extract of Moringa M. oleifera (EMO was administered at 50, 100, 200, 400 mg/kg doses orally to the respective four groups. Control was normal saline (orally at 2 ml/kg body weight). Antipyretic activity was done in albino rats using the Brewer’s yeast induced pyrexia model, standard used was paracetamol (100 mg/kg). Anti-inflammatory action was screened using carrageenan induced paw edema model in albino rats. Analgesic actions was evaluated using acetic acid induced writhing test and Eddy’s hot plate test for the peripheral and central analgesic actions respectively using albino mice. Results: The ethanolic leaf extract of M. oleifera showed significant (P rd h was 64.77% for aspirin and EMO 400 mg/kg showed 56.81% comparing with the control. Significant (P < 0.01) analgesic activity was exhibited by ethanolic leaf extract of M. oleifera at 100, 200, 400 mg/kg in both the acetic acid induced writhing test and the Eddy’s hot plate test in comparison with control. Dose-dependent increase in the percentage inhibition of writhes was noted with EMO 100, 200, 400 mg/kg showing 26%, 51% and 81%, respectively. Conclusion: Thus, our study concludes that EMO leaves has antipyretic, anti-inflammatory, and both central and peripheral analgesic actions.
机译：目的：目的是研究辣木乙醇叶提取物（通常被称为鼓槌树）的解热，消炎和镇痛活性。材料和方法：该研究是随机对照实验研究。将动物分为六组，每组六只。辣木的乙醇提取物（分别以50、100、200、400 mg / kg的剂量口服给予四个组的EMO，对照组为生理盐水（口服以2 ml / kg的体重）。使用布鲁尔酵母诱导的发热模型对白化病大鼠进行研究，标准为扑热息痛（100 mg / kg），使用角叉菜胶诱导的足爪水肿模型筛选白化病大鼠的抗炎作用，使用乙酸诱导的扭体试验和Eddy's hot评价镇痛作用平板试验分别用白化病小鼠进行外周和中枢性镇痛作用。结果：阿司匹林的乙醇叶提取物显示出显着性（P rd h为64.77％，EMO 400 mg / kg显示为56.81％，与阿司匹林相比）。与对照相比，在乙酸诱导的扭体试验和涡流热板试验中，油曲霉的乙醇叶提取物分别以100、200、400 mg / kg表现出显着的（P <0.01）镇痛作用。 -- EMO 100、200、400 mg / kg分别显示出对笔尖抑制百分比的依赖性增加，分别显示26％，51％和81％。结论：因此，我们的研究得出结论，EMO叶具有解热，抗炎作用，并且具有中枢和外周镇痛作用。

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