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首页> 外文期刊>Journal of Translational Medicine >Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
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Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

机译：Alefacept（抗CD2）导致银屑病中循环效应记忆T细胞（Tem）的选择性减少和中央记忆T细胞（Tcm）的相对保存

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Background Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. Methods Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. Results In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63% reduction) for both CD4+ and CD8+ Tem, while central memory T cells (Tcm) (CCR7+CD45RA-) were less affected, and na?ve T cells (CCR7+CD45RA+) were relatively spared. Circulating CD8+ effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. Conclusion Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
机译：背景Alefacept（抗CD2）生物疗法选择性地靶向寻常型牛皮癣（一种1型自身免疫性疾病）中的效应记忆T细胞（Tem）。方法对alefacept治疗中重度牛皮癣患者进行循环白细胞表型分析。结果在所有患者中，该治疗均导致两种CD4 + <的效应器记忆T细胞（CCR7 - CD45RA -）优先减少（平均减少63％）。 / sup>和CD8 + Tem，而中央记忆T细胞（Tcm）（CCR7 + CD45RA -）受的影响较小，并且没有？ ve T细胞（CCR7 + CD45RA + ）相对较少。循环中的CD8 + 效应子T细胞和1型T细胞（产生IFN-γ）也显着减少。结论Alefacept导致牛皮癣中循环效应记忆T细胞（Tem）的选择性减少和中枢记忆T细胞（Tcm）的相对保存。

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