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首页> 外文期刊>JRSM Cardiovascular Disease >Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: A cross-sectional study from Yaoundé, Cameroon
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Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: A cross-sectional study from Yaoundé, Cameroon

机译：患有艾滋病毒感染的非洲成年非洲人血浆的致动脉粥样硬化指数和十年的心血管疾病风险：来自喀麦隆雅温得的横断面研究

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Background The paucity of data regarding the association between atherogenic index of plasma and risk of cardiovascular disease in HIV-infected populations living in sub-Saharan Africa prompted us to conduct this study which aimed to assess the relationship between atherogenic index of plasma and risk of cardiovascular disease among a Cameroonian HIV-infected population. Methods This was a cross-sectional study conducted among 452 HIV-infected adults in Yaoundé, Cameroon. Risk of cardiovascular disease was calculated using the Framingham risk score; atherogenic index of plasma was derived as log (triglycerides/high-density lipoproteins cholesterol). Results Participants’ mean age (80% females) was 44.4?±?9.8 years. Atherogenic index of plasma values ranged from –0.63 to 1.36 with a median of 0.11 (25th–75th percentiles: –0.08-0.31). Most participants (88.5%) were on antiretroviral treatment. There was a significant correlation between atherogenic index of plasma and fasting plasma glucose (r?=?0.116; p ?=?0.014), atherogenic index of plasma and total cholesterol (r?=?–0.164; p ?
机译：背景缺乏关于在非洲撒哈拉以南地区感染HIV的人群中血浆动脉粥样硬化指数与心血管疾病风险之间关系的数据，促使我们开展这项研究，旨在评估血浆动脉粥样硬化指数与心血管疾病风险之间的关系。喀麦隆的HIV感染人群中患有这种疾病。方法这是在喀麦隆雅温得对452名受HIV感染的成年人进行的横断面研究。使用Framingham风险评分计算心血管疾病的风险;血浆的动脉粥样硬化指数导出为log（甘油三酸酯/高密度脂蛋白胆固醇）。结果参与者的平均年龄（80％为女性）为44.4±9.8岁。血浆血浆的致动脉粥样硬化指数范围为–0.63至1.36，中位数为0.11（25–75％百分位数：–0.08-0.31）。大多数参与者（88.5％）接受抗逆转录病毒治疗。血浆的动脉粥样硬化指数与空腹血糖（r = 0.116; p = 0.014），血浆的动脉粥样硬化指数和总胆固醇之间存在显着相关性（r = 0.164; p <0.001）。血浆的致动脉粥样硬化指数与心血管疾病的风险呈显着相关性（单变量（β== 5.05，95％CI：3.31-6.79; p 0.001，R〜（2）？== 0.067））或多变量校正了社会人口统计学，临床和生物学混杂因素后的线性回归模型（校正后的β？=？3.79，95％CI：1.65-4.88; p？<？0.001，R〜（2）？=？0.187）。结论血浆致动脉粥样硬化指数可能是影响喀麦隆HIV感染者心血管疾病风险的独立因素。需要进行更多的研究来更好地阐明血浆中动脉粥样硬化指数与心血管疾病风险之间的关系。

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