...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Translational Medicine >The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer
【24h】

The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer

机译：H19-IGF2印迹基因座的非编码RNA：专注于肺癌的生物学作用和治疗潜力

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described.
机译：自从首次被描述以来，据报道，印迹簇11p15.5在包括肺癌在内的各种儿科和成年癌症中均被解除调控。蛋白质编码和非编码基因均起着癌基因或抑癌基因的作用。也已经报道了可以用作癌基因或肿瘤抑制物的癌瘤。虽然完整描述11p15.5印迹簇在肺癌中所起的作用超出了本综述的范围，但我们将重点研究从H19-IGF2基因座加工的非编码RNA的作用。将特别强调H19 / miR-675基因位点。将描述其在肺癌中的潜在诊断和治疗用途。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号