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首页> 外文期刊>Journal of Translational Medicine >Microbiota and chronic inflammatory arthritis: an interwoven link
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Microbiota and chronic inflammatory arthritis: an interwoven link

机译：微生物群和慢性炎性关节炎：交织在一起的链接

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Background Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host’s health and disease. Gut microbiota in fact plays a crucial role in modulating innate and acquired immune responses and thus interferes with the fragile balance inflammation versus tolerance. Main body Correlations between gut bacteria composition and the severity of inflammation have been studied in inflammatory bowel diseases. More recently similar alterations in the gut microbiota have been reported in patients with spondyloarthritis, whereas in rheumatoid arthritis an accumulating body of evidence evokes a pathogenic role for the altered oral microbiota in disease development and course. In the context of dysbiosis it is also important to remember that different environmental factors like stress, smoke and dietary components can induce strong bacterial changes and consequent exposure of the intestinal epithelium to a variety of different metabolites, many of which have an unknown function. In this perspective, and in complex disorders like autoimmune diseases, not only the genetic makeup, sex and immunologic context of the individual but also the structure of his microbial community should be taken into account. Conclusions Here we provide a review of the role of the microbiota in the onset, severity and progression of chronic inflammatory arthritis as well as its impact on the therapeutic management of these patients. Furthermore we point-out the complex interwoven link between gut-joint-brain and immune system by reviewing the most recent data on the literature on the importance of environmental factors such as diet, smoke and stress.
机译：背景技术直到最近，科学界才了解到肠道常驻菌群对于宿主健康和疾病的重要性。肠道菌群实际上在调节先天和后天免疫应答中起着至关重要的作用，因此会干扰脆弱的炎症平衡和耐受性。在炎症性肠病中，研究了肠道细菌组成与炎症严重程度之间的主体相关性。最近，在脊椎关节炎患者中，肠道菌群也发生了类似的变化，而在类风湿性关节炎中，越来越多的证据表明，口腔菌群改变在疾病发展和病程中具有致病作用。在营养不良的情况下，还必须记住，压力，烟熏和饮食成分等不同的环境因素会引起强烈的细菌变化，进而使肠上皮暴露于多种不同的代谢产物，其中许多代谢产物的功能未知。从这个角度来看，在诸如自身免疫性疾病等复杂疾病中，不仅应考虑个体的遗传组成，性别和免疫学背景，而且还应考虑其微生物群落的结构。结论在这里，我们提供了微生物群在慢性炎性关节炎的发作，严重程度和进展中的作用及其对这些患者治疗管理的影响的综述。此外，通过回顾文献中有关饮食，烟熏和压力等环境因素重要性的最新数据，我们指出了肠-关节-脑与免疫系统之间复杂的交织关系。

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