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首页> 外文期刊>Journal of Thoracic Disease >Trophinin-associated protein expression is an independent prognostic biomarker in lung adenocarcinoma
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Trophinin-associated protein expression is an independent prognostic biomarker in lung adenocarcinoma

机译：Trophinin相关蛋白表达是肺腺癌的独立预后生物标志物

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Background: Lung cancer is the leading cause of cancer-related deaths worldwide, with lung adenocarcinoma (LAC) representing the most common subtype. Trophinin-associated protein (TROAP) is a cytoplasmic protein first identified to mediate the process of embryo transplantation, which has been recently found to be involved in microtubule regulation. However, limited information about the role of TROAP in LAC is available. Methods: We evaluated the relationship of TROAP expression in LAC tissues with clinical pathologic parameters and the survival time in LAC patients based on a statistical analysis of The Cancer Genome Atlas (TCGA) lung cancer data (N=528). Differences in survival between high and low expression groups (median expression cutoff) from the Cox univariate/multivariate regression analysis were then compared. Results: According to the Chi-square tests, we found high TROAP expression correlated with younger age (≤60) (P=0.047), male sex (P 30 pack-year) (P Conclusions: Our results suggested that TROAP is an independent prognostic biomarker of poor survival in LAC.
机译：背景：肺癌是全球范围内与癌症相关的死亡的主要原因，其中肺腺癌（LAC）代表最常见的亚型。肌钙蛋白相关蛋白（TROAP）是最早被鉴定为介导胚胎移植过程的胞质蛋白，最近发现它参与微管调控。但是，关于TROAP在LAC中的作用的信息有限。方法：我们根据对癌症基因组图谱（TCGA）肺癌数据（N = 528）的统计分析，评估了LAC组织中TROAP表达与临床病理参数和生存时间的关系。然后比较了Cox单变量/多元回归分析中高表达组和低表达组之间的生存差异（中位表达截断）。结果：根据卡方检验，我们发现TROAP的高表达与年龄较小（≤60）（P = 0.047），男性（P 30 pack-year）相关（P结论：我们的结果表明TROAP是独立的LAC生存不良的预后生物标志物。

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