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首页> 外文期刊>Journal of Thoracic Disease >Cardioplegia and myocardial protection: time for a reassessment?
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Cardioplegia and myocardial protection: time for a reassessment?

机译:心脏麻痹和心肌保护:是时候重新评估了吗?

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Since the beginnings of open cardiac surgery many different strategies have been introduced to clinical practice in order to provide a motion- and bloodless operation field. Arresting the heart with cardioplegic solutions was described by Melrose and colleagues for the first time (1). Since then cardioplegic solutions have been widely accepted as feasible and safe for the majority of cardiac operations (2). In 1981 Hearse formulated the axioms of myocardial protection during cardiac surgery: firstly cardiac arrest for the conservation of cellular energy storages; secondly hypothermia for the reduction of cellular energy demands; and thirdly application of substances to prevent or reduce ischemia-reperfusion injury (3). These axioms form the foundation for most cardioplegic solutions today.
机译:自开放性心脏手术开始以来,许多不同的策略已被引入临床实践,以提供无运动和无血的手术领域。 Melrose及其同事首次描述了使用心脏停搏液使心脏震颤(1)。从那时起,心脏停搏解决方案已被大多数心脏手术接受为可行且安全的方法(2)。 1981年,Hearse制定了心脏外科手术中心肌保护的公理:首先是心脏骤停以保存细胞能量。其次是降低细胞能量需求的体温过低;第三,使用预防或减少缺血再灌注损伤的物质(3)。这些公理构成了当今大多数心脏停搏解决方案的基础。

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