Formulation and Evaluation of an Iranian Traditional Dosage Form Containing Linum and Ficus for Improvement of Functional Constipation

Zahra Tofighi; Motahareh Golabi; Tayebeh Toliyat; Mohsen Naseri; Narguess Yassa

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Formulation and Evaluation of an Iranian Traditional Dosage Form Containing Linum and Ficus for Improvement of Functional Constipation

机译：伊朗含亚麻籽和榕树的传统剂型改善功能性便秘的配方和评价

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Background: Constipation is a common gastrointestinal problem worldwide. Objectives: The current study aimed to prepare a dosage form containing flaxseed and figs and evaluate the effects of this drug to treat functional constipation. Methods: A total of 10 formulations were developed using various proportions of excipients by wet granulation method. The best formulation containing 300 mg flaxseed powder and 1200 mg figs extract (total weight of 2000 mg) was selected. After compression of caplets, evaluation tests such as general appearance, hardness, thickness, weight variation, friability, disintegration time and standardization studies were performed. During clinical study, 15 patients with functional constipation received the prepared dosage form three times daily for two weeks, and then statistical differences within the groups were compared. Results: After the first week of experiment the increase of defecation frequency and reduction of retentive posturing, large fecal mass, pain feeling during evacuation and consistency of stool were significantly noticeable (P < 0.05). Conclusions: Prepared caplets of Linum and Ficus reduced the severity of constipation in patients.

机译：背景：便秘是全世界常见的胃肠道疾病。目的：目前的研究旨在制备含有亚麻籽和无花果的剂型，并评估该药物治疗功能性便秘的效果。方法：通过湿法制粒，使用不同比例的赋形剂开发了10种配方。选择了包含300毫克亚麻籽粉和1200毫克无花果提取物（总重量为2000毫克）的最佳配方。压缩囊片后，进行了评估测试，例如外观，硬度，厚度，重量变化，脆性，崩解时间和标准化研究。在临床研究过程中，对15例功能性便秘患者每天3次接受制备的剂型，持续2周，然后比较两组之间的统计学差异。结果：在实验的第一周后，排便频率的增加和保持姿势的减少，粪便量大，排空时的疼痛感和粪便的稠度显着（P <0.05）。结论：准备好的亚麻籽和无花果薄片降低了患者便秘的严重程度。

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《Jundishapur Journal of Natural Pharmaceutical Products》 |2017年第4期|共页
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Zahra Tofighi; Motahareh Golabi; Tayebeh Toliyat; Mohsen Naseri; Narguess Yassa;
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中图分类药理学;
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Formulation and Evaluation of an Iranian Traditional Dosage Form Containing Linum and Ficus for Improvement of Functional Constipation

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