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首页> 外文期刊>Journal of Thoracic Disease >Impact of resection margin length and tumor depth on the local recurrence after thoracoscopic pulmonary wedge resection of a single colorectal metastasis
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Impact of resection margin length and tumor depth on the local recurrence after thoracoscopic pulmonary wedge resection of a single colorectal metastasis

机译：胸腔镜肺楔形切除单个结直肠癌转移后切除边缘长度和肿瘤深度对局部复发的影响

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Background: To evaluate the influence of tumor depth on preoperative computed tomography (CT) image, and resection margin length on local recurrence after pulmonary metastasectomy of colorectal cancer. Methods: Patients undergoing thoracoscopic pulmonary wedge resection for single pulmonary metastasis of colorectal cancer origin from 2007 to 2017 were analyzed. Factors such as resection margin, tumor size and depth were analyzed. The local recurrences of two subgroups based on the pulmonary resection margin (Group 1: resection margin 1–10 mm or shorter than the tumor size, Group 2: resection margin 10 mm or at least greater than the tumor size) were analyzed. Results: Sixty-five patients were included in this study. The local recurrence rate was 12/65 (18.5%). Median follow up period was 33 months. Median tumor size and depth on preoperative CT were 1.1 and 1.6 cm. Median length of resection margin was 0.5 cm (group 1: 0.4 cm, group 2: 1.0 cm, P vs . 76.7%, P=0.756) between the two subgroups. No significant correlation was noted between the length of resection margin and the tumor size and depth. However, tumor depth was an independent factor related to higher local recurrence on multivariate analysis. Conclusions: Extent of resection margin in pulmonary metastasectomy does not seem to affect significantly on the local recurrence if complete resection is accomplished. However, preoperative tumor depth on CT image and postoperative distant metastasis seem to affect on local recurrence after pulmonary metastasectomy.
机译：背景：评价肿瘤深度对术前计算机断层扫描（CT）图像的影响，以及切除余量长度对结直肠癌肺转移切除术后局部复发的影响。方法：分析2007年至2017年因腹腔镜行肺楔形切除术的大肠癌起源的单肺转移患者。分析了诸如切缘，肿瘤大小和深度等因素。根据肺切除切缘（第1组：切除切缘比肿瘤大1-10 mm或更短，第2组：切除切缘> 10 mm或至少比肿瘤大）对两个亚组的局部复发进行分析。结果：本研究纳入了65名患者。局部复发率为12/65（18.5％）。中位随访期为33个月。术前CT的中位肿瘤大小和深度分别为1.1和1.6 cm。两个亚组之间的切除切缘中位长度为0.5 cm（组1：0.4 cm，组2：1.0 cm，P vs. 76.7％，P = 0.756）。切除切缘的长度与肿瘤大小和深度之间没有显着相关性。然而，在多变量分析中，肿瘤深度是与较高局部复发率相关的独立因素。结论：完成完全切除后，肺转移切除术的切除余量似乎对局部复发没有显着影响。然而，术前CT图像上的肿瘤深度和术后远处转移似乎影响肺转移切除术后的局部复发。

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