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首页> 外文期刊>Journal of Thoracic Disease >Pregabalin as an analgesic option for patients undergoing thoracotomy: cost analysis of pregabalin versus epidural analgesia for post-thoracotomy pain relief
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Pregabalin as an analgesic option for patients undergoing thoracotomy: cost analysis of pregabalin versus epidural analgesia for post-thoracotomy pain relief

机译：普瑞巴林作为开胸手术患者的镇痛选择：普瑞巴林与硬膜外镇痛对开胸术后疼痛的成本分析

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Background: Our previous randomized controlled trial (RCT) to evaluate the effects of pregabalin on acute post-thoracotomy pain compared with epidural analgesia showed that pregabalin is a safe and effective treatment and that it may be an alternative to epidural analgesia for acute post-thoracotomy pain. In this analysis, to additionally analyze the economic aspects of pregabalin in patients undergoing thoracotomy, we compared the medical costs between pregabalin and epidural analgesia as an analgesic technique for post-thoracotomy pain. Methods: Costs for patients undergoing thoracotomy and receiving either pregabalin or epidural analgesia for post-thoracotomy pain relief in the previous RCT were retrospectively collected from health insurance claims data. The following five cost categories were compared between the groups: (I) surgery costs; (II) costs for surgical materials and medications; (III) costs for anesthetic management; (IV) total hospitalization costs; and (V) costs for outpatient pain-relief medications (from hospital discharge to 6 months after thoracotomy). Results: We analyzed data from 90 patients (45 patients for each group). Median costs for surgical materials and medications and those for anesthetic management were significantly lower in the pregabalin group than in the epidural analgesia group [(Japanese yen) ￥69,720 vs . ￥77,180, P=0.017; ￥161,000 vs . ￥195,500, P vs . 37.5%), but median prescribed doses were much smaller in the pregabalin group. Conclusions: Although the use of pregabalin did not result in lower total hospitalization costs, it may reduce fee-for-service surgery- and anesthesia-related costs. The economic benefits of pregabalin may reinforce its usefulness as an alternative to epidural analgesia, especially for patients who are unsuitable for epidural analgesia.
机译：背景：我们以前的随机对照试验（RCT）评估普瑞巴林与硬膜外镇痛相比对开胸术后急性疼痛的影响，显示普瑞巴林是一种安全有效的治疗方法，它可能替代硬膜外镇痛用于急性开胸术后疼痛。在此分析中，为进一步分析普瑞巴林在开胸患者中的经济方面，我们比较了普瑞巴林和硬膜外镇痛之间的医疗费用，作为开胸术后疼痛的镇痛技术。方法：回顾性地从健康保险理赔数据中收集先前RCT中接受开胸手术并接受普瑞巴林或硬膜外镇痛以开胸后疼痛缓解的患者的费用。在组之间比较了以下五个费用类别：（I）手术费用; （二）手术材料和药物费用; （三）麻醉管理费用; （四）住院总费用; （V）门诊止痛药的费用（从出院至开胸后6个月）。结果：我们分析了来自90位患者（每组45位患者）的数据。普瑞巴林组的手术材料和药物以及麻醉管理的费用中位数比硬膜外镇痛组的费用中位数[69,720日元vs. ￥ 77,180，P = 0.017; ￥ 161,000。 ￥ 195,500，Pvs。 37.5％），但普瑞巴林组的中位处方剂量要小得多。结论：尽管普瑞巴林的使用并未降低总住院费用，但可以减少与手术和麻醉相关的费用。普瑞巴林的经济利益可能会增强其作为硬膜外镇痛替代方法的效用，特别是对于不适合硬膜外镇痛的患者。

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