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首页> 外文期刊>Journal of Thoracic Disease >Implications of the pulmonary artery to ascending aortic ratio in patients with relatively mild chronic obstructive pulmonary disease
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Implications of the pulmonary artery to ascending aortic ratio in patients with relatively mild chronic obstructive pulmonary disease

机译：轻度慢性阻塞性肺疾病患者肺动脉对升主动脉比率的影响

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Background: Identifying markers for predicting the course and outcome of chronic obstructive pulmonary disease (COPD) remains important. The relative pulmonary artery enlargement to aorta ratio (PA-A ratio), which is measured using computed tomography (CT), is a reported predictor for COPD exacerbation and mortality. However, little is known about the implications of the PA-A ratio in patients with mild COPD. Methods: We investigated the utility of the PA-A ratio as a biomarker in patients with relatively mild COPD. A total of 131 patients with mild to moderate COPD [post-bronchodilator forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC) 61.6±6.4, mean post-bronchodilator FEV1 83%±17.8% of predicted value] were selected from a Korean COPD cohort (from 2012 until the end of 2014) and analyzed retrospectively. We determined the correlation between the PA-A ratio and clinical parameters using a linear regression model. Results: The COPD assessment test (P=0.04), FEV1 (P=0.03), and a history of exacerbation in the last year (P=0.03) were significant factors in the univariate linear regression analysis. Post-bronchodilator FEV1 was most significantly associated with the PA-A ratio in the multivariate analysis (P=0.01). Conclusions: The PA-A ratio evaluated by CT imaging was independently correlated with a representative pulmonary function factor (FEV1) in patients with relatively mild COPD. The results suggest that the PA-A ratio may be an important biomarker for clinical outcome in patients with mild COPD.
机译：背景：确定用于预测慢性阻塞性肺疾病（COPD）病程和预后的标志物仍然很重要。使用计算机断层扫描（CT）测量的相对肺动脉增大与主动脉的比率（PA-A比率）是COPD恶化和死亡率的预测指标。然而，对于轻度COPD患者中PA-A比率的影响知之甚少。方法：我们调查了PA-A比值在较轻度COPD患者中作为生物标志物的效用。选择了131例轻度至中度COPD [支气管扩张剂后1秒钟呼气量（FEV1）/强迫肺活量（FVC）61.6±6.4，平均支气管扩张剂FEV1的83％±17.8％的预测值]来自韩国COPD队列（从2012年到2014年底），并进行了回顾性分析。我们使用线性回归模型确定了PA-A比率与临床参数之间的相关性。结果：COPD评估测试（P = 0.04），FEV1（P = 0.03）和最近一年的病情加重史（P = 0.03）是单变量线性回归分析的重要因素。在多变量分析中，支气管扩张剂后FEV1与PA-A比率最显着相关（P = 0.01）。结论：CT评估的PA-A比值与轻度COPD患者的代表性肺功能因子（FEV1）独立相关。结果表明，PA-A比率可能是轻度COPD患者临床预后的重要生物标志物。

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