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首页> 外文期刊>Journal, Indian Academy of Clinical Medicine >CDiagnostic application of conventional and newer bone marrow examination techniques in fever of unknown origin
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CDiagnostic application of conventional and newer bone marrow examination techniques in fever of unknown origin

机译：常规和较新的骨髓检查技术在不明原因发热中的诊断应用

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Introduction: Bone marrow examination (BME) including bone marrow cultures (BMC) and polymerase chain reaction (PCR) areoften used as diagnostic procedures for the evaluation of fever of unknown origin (FUO). However, objective data are limitedabout their utility in FUO.Methodology: Fifty-two patients with FUO were included in the study. After initial evaluation, BME was performed. Bone marrowaspirate was subjected to pathological examination; bacterial, fungal, and mycobacterial cultures; smear examination for AFB/LD bodies/malarial parasite, and PCR for M. tuberculosis. Bone marrow (BM) trephine was subjected to histopathologicalexamination. The diagnostic yield of BME and the number of patients in whom it was the only diagnostic modality were determined.Results: A definitive diagnosis could be achieved in 43(82.7%) patients. Thirty-two patients had infectious aetiology withextrapulmonary tuberculosis being the commonest cause of FUO. The diagnostic yield of BME was 38.6% and it was the onlydiagnostic modality in 25.6% of patients. The yield of BM aspirate smear examination was 15.4%. PCR for M. tuberculosis andfungal cultures were diagnostic in one patient each. Bacterial and mycobacterial cultures were sterile in all patients. A correlationof haematological parameters with BME showed that patients with Hb < 7.7 g% or TLC< 4,450/mm3 had a significantly higher yieldon bone marrow examination.Conclusion: Conventional BME showed a good diagnostic yield in evaluation of FUO. Newer techniques had very low diagnosticyield.
机译：简介：包括骨髓培养物（BMC）和聚合酶链反应（PCR）在内的骨髓检查（BME）通常用作诊断未知来源发热（FUO）的诊断程序。然而，关于其在FUO中的用途的客观数据有限。方法：本研究包括52例FUO患者。初步评估后，进行BME。骨髓抽吸物接受病理检查;细菌，真菌和分枝杆菌培养物;对AFB / LD体/疟原虫进行涂片检查，对结核分枝杆菌进行PCR检测。骨髓（BM）曲汀进行组织病理学检查。确定了BME的诊断率，并确定了BME是唯一诊断方法的患者人数。结果：43例（82.7％）患者可以明确诊断。 32例患者具有感染性病因，其中肺外结核是引起FUO的最常见原因。 BME的诊断率为38.6％，是25.6％的患者的唯一诊断方法。 BM抽吸物涂片检查的产率为15.4％。结核分枝杆菌和真菌培养物的PCR均诊断出一名患者。所有患者的细菌和分枝杆菌培养物均不育。血液学参数与BME的相关性表明，Hb <7.7 g％或TLC <4,450 / mm3的患者在骨髓检查中具有更高的收率。结论：常规BME对FUO的评价具有良好的诊断价值。较新的技术诊断率很低。

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