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首页> 外文期刊>Journal of Toxicologic Pathology >Fetal and Neonatal Goiter in Cynomolgus Monkeys Following Administration of the Antithyroid Drug Thiamazole at High Doses to Dams During Pregnancy
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Fetal and Neonatal Goiter in Cynomolgus Monkeys Following Administration of the Antithyroid Drug Thiamazole at High Doses to Dams During Pregnancy

机译：在怀孕期间向大坝大剂量服用抗甲状腺药噻唑之后，食蟹猴的胎儿和新生儿甲状腺肿

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To evaluate morphologic alterations in the thyroid gland in the second generation in cynomolgus monkeys, pregnant dams were exposed to high doses of thiamazole. In Experiment A, dams received thiamazole intragastrically via a nasogastric catheter from gestation day (GD) 50 to GD 150 or on the day before delivery. Initially, the dose level was 20 mg/kg/day (10 mg/kg twice daily); however, the dose level was subsequently decreased to 5 mg/kg/day (2.5 mg/kg twice daily), since deteriorated general conditions were observed in two dams. Six out of seven neonates died on the day of birth. The cause of neonatal death was tracheal compression and suffocation from goiter. The transplacental exposure to thiamazole affected the fetal thyroid glands and induced goiter in all neonates. The surviving neonate was necropsied 767 days after discontinuation of thiamazole exposure and showed reversibility of the induced changes. In Experiment B, dams were intragastrically administered thiamazole at 5 mg/kg/day (2.5 mg/kg twice daily) for treatment periods from GDs 51 to 70, 71 to 90, 91 to 110, 111 to 130 and 131 to 150. All fetuses showed enlarged thyroid glands but were viable. Histopathologically, hypertrophy and/or hyperplastic appearance of the follicular epithelium of the thyroid gland was observed at the end of each treatment period. The most active appearance of the follicular epithelium, consisting of crowded pedunculated structure, was demonstrated at end of the treatment period from GD 131 to 150. This is the first report on the morphology of fetal and neonatal goiter in the cynomolgus monkey.
机译：为了评估食蟹猴第二代甲状腺的形态变化，将孕妇大坝暴露于高剂量的噻唑下。在实验A中，水坝从妊娠50天（GD）至150天GD或分娩前一天通过鼻胃导管在胃内接受噻唑。最初，剂量水平为20 mg / kg /天（每天两次10 mg / kg）;然而，由于在两个水坝中观察到一般情况恶化，因此剂量水平随后降至5 mg / kg /天（2.5 mg / kg每天两次）。七分之一的新生儿在出生当天死亡。新生儿死亡的原因是甲状腺肿大导致气管压迫和窒息。经胎盘接触噻唑影响所有新生儿的胎儿甲状腺，并诱发甲状腺肿。终止噻唑暴露后767天，对幸存的新生儿进行了尸检，并显示出诱导变化的可逆性。在实验B中，以GDs 51至70、71至90、91至110、111至130和131至150的腹膜内对大坝进行5 mg / kg /天（每天两次，2.5 mg / kg每天两次）的胃内给药。胎儿的甲状腺增大，但可行。组织病理学上，在每个治疗期结束时观察到甲状腺滤泡上皮的肥大和/或增生。在治疗期末（从131 GD到150 GD），卵泡上皮的最活跃外观由拥挤的有蒂结构组成。这是关于食蟹猴胎儿和新生儿甲状腺肿形态的首次报道。

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