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首页> 外文期刊>Journal of the Association of Physicians of India >Association of Plasma Homocysteine and Insulin Resistance in Coronary Artery Disease
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Association of Plasma Homocysteine and Insulin Resistance in Coronary Artery Disease

机译：血浆同型半胱氨酸与冠状动脉疾病中胰岛素抵抗的关系

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Objectives: Although insulin resistance and hyperhomocysteinemia may both be associated with endothelial dysfunction and cardiovascular disease, associations between them in coronary artery disease (CAD) are not well characterized. We investigated association between insulin resistance and homocysteine in CAD. Methods: One hundred thirty subjects were studied. Of these sixty-five were angiographically documented CAD patients and 65 subjects were without CAD as documented by normal stress test and 2D echo. Fasting levels of plasma homocysteine, serum vitamin B12, folic acid, insulin, insulin resistance (HOMA-IR), lipid parameters, along with BMI and blood pressure levels were estimated. The prevalence of hyperhomocysteinemia (>15 μmol//) and insulin resistance (HOMA-IR>4.65 or BMI>27.5 kg/m2 and HOMAI-IR>3.6) and reduced vitamin B12 ( Result: Significantly raised levels of insulin resistance, homocysteine, LDL cholesterol, triglycerides, insulin levels were observed among the cases compared to the controls. Among the CAD subjects, hyperhomocysteinemia was observed in 22 (33.3%) subjects, raised insulin resistance in 21 (32.31% subjects), and dyslipidemia in 34 (53.4%) subjects. We also observed reduced levels of vitamin B12 and folic acid in blood among 23 (35.1%) CAD patients. There was no significant difference in age and gender between the case and control groups. There was a significant difference in prevalence (case vs. controls) of smoking (32.8% vs 12.3%), hypertension (38.5% vs. 1.2 %) and diabetes (27.7% vs. 4.3 %). On comparing the insulin resistant CAD subjects with the insulin non-resistant CAD subjects, we observed significantly raised (p Conclusion: We observed that both insulin resistance and homocysteine were significantly and independently associated with CAD risk. There was also a significant association between plasma homocysteine and insulin resistance in CAD subjects.
机译：目的：尽管胰岛素抵抗和高同型半胱氨酸血症都可能与内皮功能障碍和心血管疾病有关，但它们在冠状动脉疾病（CAD）中的关联尚不明确。我们调查了CAD中胰岛素抵抗与高半胱氨酸之间的关联。方法：研究一百三十名受试者。在这65名患者中，有血管造影记录的CAD患者，而65名受试者没有CAD，这是通过正常压力测试和2D回声记录的。估计血浆同型半胱氨酸，血清维生素B12，叶酸，胰岛素，胰岛素抵抗（HOMA-IR），脂质参数以及BMI和血压水平的禁食水平。高同型半胱氨酸血症（> 15μmol//）的患病率和胰岛素抵抗（HOMA-IR> 4.65或BMI> 27.5 kg / m2和HOMAI-IR> 3.6）和维生素B12减少（结果：胰岛素抵抗，同型半胱氨酸，与对照组相比，在这些病例中观察到LDL胆固醇，甘油三酸酯，胰岛素水平;在CAD受试者中，高同型半胱氨酸血症发生在22名（33.3％）受试者中，其中21名胰岛素抵抗升高（32.31％受试者），血脂异常在34名（53.4％）。此外，我们还观察到23名（35.1％）的CAD患者血液中维生素B12和叶酸水平降低。病例与对照组之间的年龄和性别无显着差异。吸烟（32.8％vs. 12.3％），高血压（38.5％vs. 1.2％）和糖尿病（27.7％vs. 4.3％），胰岛素抵抗性CAD患者和非胰岛素抵抗性CAD患者的比较，我们观察到明显升高（p结论：观察到胰岛素抵抗和同型半胱氨酸均与CAD风险显着且独立相关。在CAD受试者中血浆同型半胱氨酸与胰岛素抵抗之间也存在显着关联。

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