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首页> 外文期刊>Diabetes, metabolic syndrome and obesity: targets and therapy >Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
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Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men

机译：代谢综合征与男性外周血管内皮功能障碍有关

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Purpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED. Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index ≥ 25 kg/m,sup2/sup impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol. Results: Six hundred seventy-eight patients were included (mean age 51.9±13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P =0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P =0.0094). Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.
机译：目的：代谢综合征（MetS）和外周血管内皮功能障碍（PED）都与心血管疾病（CVD）风险增加独立相关。 PED提供的预后信息超出了常规风险因素所提供的信息。但是，MetS和PED之间的关联仍不确定。我们评估了MetS和PED之间的关联。患者和方法：我们对2006年至2014年间转诊至Mayo诊所进行胸痛评估和/或CVD风险评估的患者进行了回顾性分析，其中包括通过反应性充血外周动脉眼压测量法评估PED。 MetS被定义为存在以下至少3种：体重指数≥25 kg / m， 2 空腹血糖或糖尿病受损，高血压或高血压，高甘油三酯血症或低密度人群脂蛋白胆固醇。结果：共纳入678例患者（平均年龄51.9±13.5岁，女性418位（61.6％）），其中PED 293位（43.2％），MetS 249位（36.7％）。在根据年龄，性别，CVD，吸烟状况和低密度脂蛋白升高进行的多变量分析中，MetS与PED显着相关（几率（OR）2.06; P = 0.0090）。在单独的MetS成分中，只有超重和MetS范围的高密度脂蛋白具有相似的关联。按性别分层后，MetS和PED之间的关联仅在男性中持续存在（OR 3.16，P = 0.0094）。结论：在评估胸痛和/或CVD风险的男性中，MetS与PED相关。在患有MetS的个体中鉴定PED可以对风险进行简化评估，从而有可能实现对风险因素的更早，更深入的管理。

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