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首页> 外文期刊>Diabetes, metabolic syndrome and obesity: targets and therapy >The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
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The association between omentin and diabetes: a systematic review and meta-analysis of observational studies

机译：omentin与糖尿病之间的关联：观察性研究的系统评价和荟萃分析

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Aims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population. Methods: PubMed, Cochrane’s Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle–Ottawa Quality Assessment Scale was used to assess the quality of each study. Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD?1.68; 95% CI, ?2.17 to ?1.19; P 0.001). The result of our sub-group analysis based on participants’ health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls. Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.
机译：目的：许多研究检查了网膜蛋白水平与糖尿病之间的关系，但结论尚无定论。在本文中，我们系统地综述了可用的观察性研究，以阐明网膜蛋白与糖尿病之间的总体关系，包括青少年和成人人群中的1型糖尿病（T1DM），2型糖尿病（T2DM）和糖耐量降低（IGT）。方法：直到2019年1月，才搜索PubMed，Cochrane图书馆，Science Direct，Scopus，Google Scholar和ISI Web of Science数据库中所有可用的文献，以评估网膜素与糖尿病之间的关联性。纽卡斯尔-渥太华质量评估量表用于评估每项研究的质量。结果：共有28篇符合入选标准的文章被纳入我们的系统评价和荟萃分析。血清网膜蛋白与糖尿病之间存在显着相关性（WMD≤1.68; 95％CI，≤2.17至≤1.19; P <0.001）。我们根据参与者的健康状况进行的亚组分析结果显示，与健康对照组相比，T2DM和IGT受试者中的omentin显着降低，而T1DM受试者中的omentin则较低。结论：我们发现T2DM和IGT患者的血清omentin水平显着降低，而T1DM患者则没有。临床医生可以将这些数据用于糖尿病的早期诊断和管理。此外，我们需要更多的临床试验来研究可能影响网膜蛋白水平的新药物。

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