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首页> 外文期刊>Diabetes, metabolic syndrome and obesity: targets and therapy >Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
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Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

机译：藏红花对2型糖尿病患者炎症和代谢反应的影响：一项随机，双盲，安慰剂对照的试验

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Background: Type 2 diabetes (T2D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T2D. Patients and methods: This randomized controlled trial included 80 T2D patients with a mean age of 54.1 years. Participants were randomly assigned into two groups to take either saffron tablets (100 mg/day; n=40) or placebo (n=40) for 12 weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile, and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end. Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference ( p 0.001) and malondialdehyde (MDA) ( p =0.001). There was no statistically significant difference in other indices, including anthropometric parameters, serum insulin, fasting blood glucose, HbA1c, insulin sensitivity indices, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, and tumor necrosis factor-α between the study groups ( p 0.05). Conclusion: Overall, 12 weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum MDA levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients.
机译：背景：2型糖尿病（T2D）伴随着炎症增加，氧化应激，高脂血症和高血糖症，这些都与心血管疾病的发病机理有关。藏红花作为补充药物和抗氧化剂的来源可以在减轻糖尿病及其并发症中发挥作用。这项研究的目的是确定藏红花补充剂作为T2D辅助治疗的效果。患者和方法：这项随机对照试验包括80名T2D患者，平均年龄为54.1岁。参与者被随机分为两组，分别服用藏红花片（100毫克/天; n = 40）或安慰剂（n = 40），持续12周。在干预开始时和干预后均获取空腹血样，以量化血糖因素，脂质分布以及炎症和氧化应激的生物标志物。在基线和研究结束时还测量了人体测量指标和饮食摄入量。结果：与安慰剂相比，番红花的补充导致腰围（p <0.001）和丙二醛（MDA）显着减少（p = 0.001）。在其他指标之间，包括人体测量学参数，血清胰岛素，空腹血糖，HbA1c，胰岛素敏感性指标，脂质谱，高敏感性C反应蛋白，总抗氧化能力和肿瘤坏死因子-α，其他指标均无统计学差异。研究组（p> 0.05）。结论：总体而言，糖尿病患者补充藏红花12周对腰围和血清MDA水平具有有益的作用。然而，藏红花并没有影响糖尿病患者其他经评估的心脏代谢风险指标。

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