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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >Complete genome analysis of a rare group A rotavirus, G11P[25], isolated from a child in Mumbai, India, reveals interspecies transmission and reassortment with human rotavirus strains
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Complete genome analysis of a rare group A rotavirus, G11P[25], isolated from a child in Mumbai, India, reveals interspecies transmission and reassortment with human rotavirus strains

机译：从印度孟买一名儿童中分离出的一种罕见的A组轮状病毒G11P [25]的完整基因组分析，揭示了人类轮状病毒株之间的种间传播和重配。

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摘要

Hospital-based rotavirus surveillance was carried out in Mumbai during 2005–2009. An isolate (B08299) with a rare genotype combination (G11P[25]) was detected. The present study was undertaken to characterize the complete genome of the isolate. B08299 exhibited a G11–P[25]–I12–R1–C1–M1–A1–N1–T1–E1–H1 genotype constellation. Phylogenetic analysis of the 11 gene segments of B08299 revealed that the VP2 and NSP5 genes of B08299 had a human origin, while the VP6 gene represented an I12 genotype of obscure origin. The remaining six genes formed a lineage distinct from human and porcine rotaviruses within genotype 1. Analysis of the structural and non-structural genes suggested that B08299 has evolved by gene reassortment. Our findings provide further evidence that interspecies transmission is an important mechanism involved in the evolution and genetic diversity of human rotaviruses in nature.
机译：2005-2009年期间，在孟买进行了以医院为基础的轮状病毒监测。检测到具有罕见基因型组合（G11P [25]）的分离株（B08299）。进行本研究以表征分离物的完整基因组。 B08299显示了G11–P [25] –I12–R1–C1–M1–A1–N1–T1–E1–H1基因型星座。对B08299的11个基因区段的系统进化分析表明，B08299的VP2和NSP5基因具有人类起源，而VP6基因则代表了I12基因型的起源。其余六个基因形成了与基因型1内的人和猪轮状病毒不同的谱系。对结构和非结构基因的分析表明B08299已通过基因重排进化。我们的发现提供了进一步的证据，表明种间传播是参与人类轮状病毒自然进化和遗传多样性的重要机制。

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