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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control
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Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control

机译：医疗保健相关感染，医疗设备和生物膜：风险，耐受性和控制

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摘要

Biofilms are of great importance in infection control and healthcare-associated infections owing to their inherent tolerance and ‘resistance’ to antimicrobial therapies. Biofilms have been shown to develop on medical device surfaces, and dispersal of single and clustered cells implies a significant risk of microbial dissemination within the host and increased risk of infection. Although routine microbiological testing assists with the diagnosis of a clinical infection, there is no ‘gold standard’ available to reveal the presence of microbial biofilm from samples collected within clinical settings. Furthermore, such limiting factors as viable but non-culturable micro-organisms and small-colony variants often prevent successful detection. In order to increase the chances of detection and provide a more accurate diagnosis, a combination of microbiological culture techniques and molecular methods should be employed. Measures such as antimicrobial coating and surface alterations of medical devices provide promising opportunities in the prevention of biofilm formation on medical devices.
机译：生物膜由于其固有的耐受性和对抗菌疗法的“抵抗力”，因此在感染控制和医疗保健相关感染中非常重要。生物膜已显示在医疗器械表面上生长，单个细胞和簇状细胞的散布意味着微生物在宿主内散布的风险很高，感染的风险也更高。尽管常规的微生物学检测有助于诊断临床感染，但尚无“金标准”可用于揭示临床环境中收集的样品中是否存在微生物生物膜。此外，诸如生存但不可培养的微生物和小菌落变体等限制因素通常会妨碍成功检测。为了增加检测的机会并提供更准确的诊断，应结合使用微生物培养技术和分子方法。诸如抗菌涂层和医疗器械表面改变等措施为预防医疗器械上生物膜的形成提供了有希望的机会。

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