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首页> 外文期刊>Journal of Research in Medical and Dental Science >Design and Formulation of Inorganic Dispersed Organogel for Hemostasis
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Design and Formulation of Inorganic Dispersed Organogel for Hemostasis

机译：止血用无机分散有机凝胶的设计与配方

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Hemostasis occurs by dehydrating the injury site, concentrating clotting factors, delivering clotting agents such as thrombin and fibrinogen or forming a physical barrier against bleeding. Introducing an economical alternative to thrombin and fibrinogen based injectable solutions, which has a risk of strong coagulation activation into the circulatory system is the main objective. To form a physical barrier against bleeding an organogel base (hydrocarbon type) was chosen. Colloidal silicone dioxide was dispersed in mineral oil and vitamin K1 (phytonadione) under a mixer to form a powder gel base. Sifted Kaolin (Al2Si2O5(OH)4), a crystalline mineral, was dispersed in ultrapure water using a propeller mixer to form an inorganic gel. Once in the wound the material should solidify to prevent its loss to unaffected areas. Hence, sifted carbopol 974P NF was spread in ultrapure water using a propeller mixer. These two aqueous phases were added to the organogel base using a sorbitol-based nonionic surfactant (1%), sorbitan sesquioleate under a homogenizer to transport the aqueous phases into a main continuous phase. Comparing the viscosity results of F6 and F7, F7 showed a higher viscosity. Viscosity reduction due to increase in shear rate was slighter for F7 in comparison to F6. Introducing an organogel base to form a physical barrier, Kaolin, which functions as an absorbent and coagulation activator (Factor XII), vitamin K1, which has an effect on é￡-carboxylation of coagulation factors and healing wounds, carbopol 974P NF, which is an excellent mucoadhesive showed a promising economical approach for hemostasis.
机译：止血是通过使损伤部位脱水，浓缩凝血因子，输送凝血酶（如凝血酶和纤维蛋白原）或形成物理上的防渗屏障而发生的。主要目的是引入一种经济的替代方法，以替代凝血酶和血纤蛋白原的可注射溶液，这可能会强烈地激活凝血系统。为了形成防止渗出的物理屏障，选择了有机凝胶碱（烃类）。在混合机下将胶体二氧化硅分散在矿物油和维生素K1（植物二酮）中，形成粉末凝胶基质。使用螺旋桨混合器将筛分的高岭土（Al2Si2O5（OH）4）（一种晶体矿物）分散在超纯水中，以形成无机凝胶。一旦进入伤口，材料应固化以防止其流失到未受影响的区域。因此，使用螺旋桨混合机将筛过的卡波普974P NF分散在超纯水中。在均化器下使用基于山梨醇的非离子表面活性剂（1％），脱水山梨醇倍半油酸酯将这两个水相添加至有机凝胶基质中，以将水相输送至主要连续相中。比较F6和F7的粘度结果，F7显示出较高的粘度。与F6相比，F7因剪切速率增加而导致的粘度降低要小一些。引入有机凝胶碱以形成物理屏障，高岭土用作吸收和凝血活化剂（因子XII），维生素K1，对凝血因子和羧化伤口的羧化有影响，carbopol 974P NF是出色的粘膜黏附剂显示了一种有希望的止血经济方法。

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