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首页> 外文期刊>Journal of spectroscopy >Different Spectrophotometric Methods Manipulating Ratio Spectra Applied for the Analysis of Aclidinium in Duaklir® Genuair® Inhalation Powder
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Different Spectrophotometric Methods Manipulating Ratio Spectra Applied for the Analysis of Aclidinium in Duaklir® Genuair® Inhalation Powder

机译：不同分光光度法处理比例​​光谱用于Duaklir®Genuair®吸入粉中的Aclidinium分析

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摘要

Two simple, accurate, and selective spectrophotometric methods were developed to determine aclidinium in the presence of formoterol as interferent compound in Duaklir Genuair inhalation powder. The methods under study are ratio derivative and ratio subtraction spectrophotometric methods. These methods are based on different mathematical processing of the obtained ratio spectra. The methods are linear over the concentration range of 5–50 µg/mL for aclidinium and validated according to the ICH guidelines. The accuracy and precision are found to be within the acceptable limits and assessed by applying the standard addition technique. The specificity of the proposed methods was tested using laboratory-prepared mixtures. Furthermore, the methods were statistically compared to the reported RP-HPLC method, and good results were obtained.
机译：开发了两种简单，准确和选择性的分光光度法，在Duaklir Genuair吸入粉中存在福莫特罗作为干扰化合物的情况下测定阿立地铵。所研究的方法是比率导数和比率减法分光光度法。这些方法基于获得的比率光谱的不同数学处理。该方法在阿魏地平的浓度范围为5-50μg/ mL时是线性的，并根据ICH指南进行了验证。发现准确性和精确度在可接受的范围内，并通过应用标准添加技术进行评估。建议的方法的特异性使用实验室制备的混合物进行测试。此外，将该方法与报告的RP-HPLC方法进行了统计比较，并获得了良好的结果。

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