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首页> 外文期刊>Journal of spectroscopy >Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method
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Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method

机译：一阶导数紫外分光光度法同时估算散装和混合剂型中布洛芬和盐酸去氧肾上腺素

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摘要

A simple, precise, rapid, and economic method was developed for the simultaneous determination of Ibuprofen and Phenylephrine HCl in bulk and combined dosage form. This method involves first-order derivative spectroscopy using 248 nm and 237 nm as zero crossing points for Ibuprofen and Phenylephrine HCl, respectively. For spectrophotometric method 0.1 N NaOH was used as a solvent. The linearity was established over the concentration range of 12–72 μg/mL and 1.5–22 μg/mL for Ibuprofen and Phenylephrine HCl with correlation coefficient (r2) of 0.9972 and 0.9981, respectively. The mean % recoveries were found to be in the range of 98.88% and 98.54% for Ibuprofen and Phenylephrine HCl, respectively. Interday and intraday studies showed repeatability of the method. The method was found to be specific and robust. The method was successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study. Results of analysis were validated statistically and by recovery studies.
机译：开发了一种简单，精确，快速且经济的方法，用于同时测定散装和组合剂型中的布洛芬和盐酸去氧肾上腺素。该方法涉及一阶导数光谱，分别使用248 nm和237 nm作为布洛芬和盐酸去氧肾上腺素的零交叉点。对于分光光度法，使用0.1 N NaOH作为溶剂。在布洛芬和盐酸去氧肾上腺素的浓度范围为12–72μg / mL和1.5–22μg / mL的范围内建立线性关系，相关系数（r2）分别为0.9972和0.9981。发现布洛芬和盐酸去氧肾上腺素的平均回收率分别在98.88％和98.54％的范围内。日间和日内研究表明该方法的可重复性。发现该方法是特定且可靠的。该方法已成功应用于药物制剂，回收率研究表明该方法不受辅料的干扰。分析结果通过统计学和回收率研究进行了验证。

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