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首页> 外文期刊>BioMed research international >Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression
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Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression

机译：miRNA基因簇和基因家族的全局分析揭示了动态和协调的表达。

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To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and clustered and homologous miRNAs may have close relationships with overlapped miRNA species. Members in the miRNA group always had various expression levels, and even some showed larger expression divergence. Despite the dynamic expression as well as individual difference, these miRNAs always indicated consistent or similar deregulation patterns. The consistent deregulation expression may contribute to dynamic and coordinated interaction between different miRNAs in regulatory network. Further, we found that those clustered or homologous miRNAs that were also identified as sense and antisense miRNAs showed larger expression divergence. miRNA gene clusters and families indicated important biological roles, and the specific distribution and expression further enrich and ensure the flexible and robust regulatory network.
机译：为了进一步了解miRNA在miRNA基因簇和基因家族中的潜在表达关系，使用深度测序数据集对4对配对的肿瘤（乳腺癌）和邻近的正常组织样本进行了全局分析。 miRNA基因簇和家族的组成不是随机的，成簇和同源的miRNA可能与重叠的miRNA种类有密切的关系。 miRNA组中的成员始终具有各种表达水平，甚至有些成员表现出更大的表达差异。尽管存在动态表达以及个体差异，但这些miRNA始终显示出一致或相似的去调控模式。一致的去调节表达可能有助于调节网络中不同miRNA之间的动态和协调相互作用。此外，我们发现那些也被识别为有义和反义miRNA的簇状或同源miRNA表现出更大的表达差异。 miRNA基因簇和家族表明重要的生物学作用，其特定的分布和表达进一步丰富并确保了灵活而强大的调控网络。

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