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首页> 外文期刊>BioMed research international >The Diagnostic Value of18F-FDG PET/CT in Association with Serum Tumor Marker Assays in Breast Cancer Recurrence and Metastasis
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The Diagnostic Value of18F-FDG PET/CT in Association with Serum Tumor Marker Assays in Breast Cancer Recurrence and Metastasis

机译：18F-FDG PET / CT结合血清肿瘤标志物检测对乳腺癌复发转移的诊断价值

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Background. After initial treatment of breast cancer (BC), monitoring locoregional recurrence and distant metastases is a great clinical challenge.Objective. To evaluate the efficacy of PET/CT in association with serum tumor makers in BC follow-up.Methods. Twenty-six women with a history of modified radical mastectomy were evaluated by18F-FDG PET/CT. The results of PET/CT were compared with those of conventional imaging techniques (CITs) (including mammography, chest radiography, CT, MRI, ultrasound, and bone scintigraphy). Serum tumor markers of CEA, CA 125, and CA 15-3 in the BC patients were also analyzed in association with the results of PET/CT.Results. Compared with CITs, PET/CT was more sensitive to detect the malignant foci and had better patient-based sensitivity and specificity. The mean CA 15-3 serum level was significantly higher in the confirmed positive patients of PET/CT results than in the confirmed negative ones, while there were no significant differences in the serum levels of CEA and CA 125 of both groups.Conclusion. PET/CT is a highly efficient tool for BC follow-up compared with CITs. The high serum levels of CA 15-3 in confirmed positive PET/CT patients indicated the clinical value of CA 15-3 in BC follow-up.
机译：背景。在对乳腺癌（BC）进行初步治疗后，监测局部复发和远处转移是一项巨大的临床挑战。评估PET / CT联合血清肿瘤产生者在BC随访中的疗效。通过18F-FDG PET / CT评估了26例接受过改良根治术的女性。将PET / CT的结果与常规成像技术（CIT）（包括乳房X线照片，胸部X线照片，CT，MRI，超声和骨闪烁显像）进行比较。还结合PET / CT结果分析了BC患者的CEA，CA 125和CA 15-3血清肿瘤标志物。与CITs相比，PET / CT对恶性灶的检测更加敏感，并且基于患者的敏感性和特异性更高。确诊的PET / CT结果阳性患者的平均CA 15-3血清水平显着高于确诊的阴性患者，而两组中CEA和CA 125的血清水平无显着差异。与CIT相比，PET / CT是进行BC随访的高效工具。在确诊的PET / CT阳性患者中，血清CA 15-3的水平较高，表明CA 15-3在BC随访中具有临床价值。

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