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首页> 外文期刊>BMC Genomics >A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL
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A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL

机译：猪基因组性状的二维基因组扫描显示存在多个上位性QTL

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Background Prolificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement of this trait through artificial selection. Moreover, the relative contributions of additive, dominant and epistatic QTL to the genetic variance of pig prolificacy remain to be defined. In this work, we have undertaken this issue by performing one-dimensional and bi-dimensional genome scans for number of piglets born alive (NBA) and total number of piglets born (TNB) in a three generation Iberian by Meishan F2 intercross. Results The one-dimensional genome scan for NBA and TNB revealed the existence of two genome-wide highly significant QTL located on SSC13 (P SSC17 (P P P P P Conclusions The complex inheritance of prolificacy traits in pigs has been evidenced by identifying multiple additive (SSC13 and SSC17), dominant and epistatic QTL in an Iberian × Meishan F2 intercross. Our results demonstrate that a significant fraction of the phenotypic variance of swine prolificacy traits can be attributed to first-order gene-by-gene interactions emphasizing that the phenotypic effects of alleles might be strongly modulated by the genetic background where they segregate.
机译：背景高产是影响养猪生产系统繁殖效率的最重要特征。低遗传力和多产的性别限制表达在某种程度上阻碍了通过人工选择来改善该性状。此外，加性，显性和上位性QTL对猪多产遗传变异的相对贡献仍有待确定。在这项工作中，我们通过一维和二维基因组扫描梅山F 2在三代伊比利亚人中活着的仔猪数量（NBA）和仔猪总数（TNB）进行了研究。 交叉。结果对NBA和TNB进行的一维基因组扫描揭示了位于SSC13（P SSC17（PPPPP）上的两个全基因组高度重要QTL的存在结论已通过鉴定多种添加剂（SSC13和SSC17）证明了猪多能性状的复杂遗传），伊比利亚×梅山F 2 杂交中的显性和上位QTL。我们的研究结果表明，猪多产性状的大部分表型变异可归因于一阶基因间的相互作用强调等位基因的表型效应可能受到它们分离的遗传背景的强烈调节。

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