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首页> 外文期刊>BMC Genomics >Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points
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Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points

机译：协作型交叉小鼠对肺炎克雷伯菌感染的易感性是一个复杂的性状，受至少三个在不同时间点起作用的基因座控制

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Background Klebsiella pneumoniae (Kp) is a bacterium causing severe pneumonia in immunocompromised hosts and is often associated with sepsis. With the rise of antibiotic resistant bacteria, there is a need for new effective and affordable control methods; understanding the genetic architecture of susceptibility to Kp will help in their development. We performed the first quantitative trait locus (QTL) mapping study of host susceptibility to Kp infection in immunocompetent Collaborative Cross mice (CC). We challenged 328 mice from 73 CC lines intraperitoneally with 104 colony forming units of Kp strain K2. Survival and body weight were monitored for 15?days post challenge. 48 of the CC lines were genotyped with 170,000 SNPs, with which we mapped QTLs. Results CC lines differed significantly (P? Conclusion Host susceptibility to Kp is a complex trait, controlled by multiple genetic factors that act sequentially during the course of infection.
机译：背景技术肺炎克雷伯氏菌（Kp）是一种在免疫功能低下的宿主中引起严重肺炎的细菌，通常与败血症相关。随着抗生素抗性细菌的兴起，需要新的有效且负担得起的控制方法。了解Kp易感性的遗传结构将有助于其发展。我们进行了第一个定量性状基因座（QTL）作图研究，研究了宿主在免疫能力强的交叉杂交小鼠（CC）中对Kp感染的敏感性。我们腹膜内攻击来自73个CC系的328只小鼠，其中Kp菌株K2的10 4 集落形成单位。攻击后15天监测存活率和体重。我们对48条CC品系进行了170,000个SNP的基因分型，并以此绘制了QTL。结果CC系差异显着（P？结论宿主对Kp的敏感性是一个复杂的性状，受感染过程中依次起作用的多种遗传因素控制。

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