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首页> 外文期刊>BMJ Open >Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study
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Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study

机译：在几内亚比绍的艾滋病毒感染患者中，在诊断和随访期间的所有阶段均发生随访损失：一项为期7年的回顾性队列研究

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Objectives To describe loss to follow-up (LTFU) at all stages of the HIV programme. Design A retrospective cohort study. Setting The HIV clinic at Hospital National Sim?o Mendes in Bissau, Guinea-Bissau. Participants A total of 4080 HIV-infected patients. Outcome measures Baseline characteristics, percentages and incidence rates of LTFU as well as LTFU risk factors at four different stages: immediately after HIV diagnosis (stage 1), after the first CD4 cell count and before a follow-up consultation (stage 2), after a follow-up consultation for patients not eligible for antiretroviral treatment (ART; stage 3) and LTFU among patients on ART (stage 4). Results Almost one-third of the patients were lost to the programme before the first consultation where ART initiation is decided; during the 7-year observation period, more than half of the patients had been lost to follow-up (overall incidence rate=51.1 patients lost per 100 person-years). Age below 30?years at inclusion was a risk factor for LTFU at all stages of the HIV programme. The biggest risk factors were body mass index 18.5?kg/m2 (stage 1), male gender (stage 2), HIV-2 infection (stage 3) and CD4 cell count 200 cells/μL (stage 4). Conclusions In this study, LTFU constituted a major problem, and this may apply to other similar ART facilities. More than half of the patients were lost to follow-up shortly after enrolment, possibly implying a high mortality. Thus, retention should be given a high priority.
机译：目的描述在艾滋病项目的各个阶段的随访损失（LTFU）。设计回顾性队列研究。在几内亚比绍比绍的国家Sim？o Mendes医院设置艾滋病诊所。参与者共有4080名HIV感染患者。成果指标在四个不同阶段的基线特征，LTFU的百分比特征，发生率以及LTFU危险因素：在HIV诊断后（第1阶段），首次CD4细胞计数后和随访会诊（第2阶段）之后，之后对不接受抗逆转录病毒治疗（ART;第3期）和LTFU的患者（第4期）进行随访。结果在决定进行抗逆转录病毒治疗的第一次会诊之前，将近三分之一的患者迷失了该程序。在7年的观察期内，有一半以上的患者丢失了随访（总发生率=每100人年丢失51.1名患者）。在艾滋病项目的所有阶段，纳入的30岁以下年龄是LTFU的危险因素。最大的危险因素是体重指数<18.5？kg / m 2 （第1阶段），男性（第2阶段），HIV-2感染（第3阶段）和CD4细胞计数<200个细胞/ μL（阶段4）。结论在这项研究中，LTFU构成了一个主要问题，这可能适用于其他类似的ART设施。入组后不久有一半以上的患者失去随访，可能意味着死亡率高。因此，应高度重视保留。

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