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首页> 外文期刊>British Journal of Cancer >Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
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Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone

机译：粗大鼠肝组蛋白治疗细胞的恶性行为增强

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Neonatal hamster kidney cells (BHK21/C13), challenged in monolayer culture for three days with crude rat liver histone, have been shown to exhibit increased malignant characteristics when injected subcutaneously into hamsters. In contrast to the controls, the challenged cells produced tumours which invaded either the epidermis or the body wall of their hosts and frequently caused extensive visceral metastases. in vitro studies of the cell cultures, during and after histone treatment, suggested that cellular “transformation” rather than selection was effected by the crude histone preparation. Cells from the primary tumours of both control and test groups appeared morphologically identical but after sub-culture in vitro they retained their respective growth characteristics on reinoculation.
机译：新生的仓鼠肾细胞（BHK21 / C13）在大鼠单层培养中用大鼠肝组织粗蛋白攻击了三天，经皮下注射到仓鼠中显示出增强的恶性特征。与对照相比，受攻击的细胞产生的肿瘤会侵袭其宿主的表皮或体壁，并经常引起广泛的内脏转移。在组蛋白处理期间和之后对细胞培养物进行的体外研究表明，粗组蛋白制备可实现细胞的“转化”而不是选择。来自对照组和测试组的原发性肿瘤的细胞在形态上看起来相同，但是在体外亚培养后，它们在重新接种后仍保持各自的生长特性。

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