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首页> 外文期刊>British Journal of Cancer >Cellular immunocompetence in melanoma: effect of extent of disease and immunotherapy
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Cellular immunocompetence in melanoma: effect of extent of disease and immunotherapy

机译：黑色素瘤的细胞免疫能力：疾病程度和免疫疗法的影响

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Cell mediated immunocompetence was measured serially in 35 patients with malignant melanoma in order to determine the effect of extent of disease and prognosis as well as the influence of BCG immunotherapy on immune reactivity. Compared with normal adult controls, statistically significant lymphopenia occurred only in patients with widespread disease. Seventeen of 21 patients with negative pre-therapy PPD skin test converted to skin test positivity. PHA blastogenesis was depressed only in patients in the pre-terminal stages of their disease using optimal mitogen concentrations for stimulation. Threshold concentrations of this mitogen more clearly demonstrated a depressed responsiveness which correlated in severity with extent of disease. PPD induced blastogenesis was normal or increased in the majority of patients; however, the degree of stimulation by PPD was less in the BCG induced convertors than in those patients who were skin test positive before BCG treatment. Comparison of the pre- and post BCG assessments reveals no significant differences except in relation to PPD conversion. We conclude that using threshold concentrations of PHA, impaired responses are regularly associated with disease beyond the regional lymph nodes. Routine assessment of lymphocyte function by these parameters did not provide information that was not available from clinical evaluation.
机译：为了确定疾病程度和预后以及BCG免疫疗法对免疫反应性的影响，对35例恶性黑色素瘤患者进行了细胞介导的免疫能力测定。与正常成人对照组相比，统计学上显着的淋巴细胞减少仅发生在广泛疾病患者中。治疗前PPD皮肤测试阴性的21例患者中有17例转化为皮肤测试阳性。使用最佳促细胞分裂剂浓度刺激的患者，仅在疾病前期阶段的患者中抑制PHA的成骨作用。该促分裂原的阈值浓度更清楚地显示出反应性降低，其严重程度与疾病程度相关。在大多数患者中，PPD诱导的成胚作用正常或增加;但是，在BCG诱导的转化子中，PPD的刺激程度要比在BCG治疗之前皮肤测试呈阳性的患者少。比较BCG之前和之后的评估发现，除PPD转换外，没有显着差异。我们得出结论，使用阈值浓度的PHA，受损的反应通常与区域淋巴结以外的疾病有关。这些参数对淋巴细胞功能的常规评估未提供临床评估无法获得的信息。

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